Exam 1 Drugs MOA_Uses Flashcards Preview

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Flashcards in Exam 1 Drugs MOA_Uses Deck (42):
1

Primaquine

MOA: Unknown-Maybe ROS Uses:Hypnozoites in ovale and vivax; Only drug against hypnozoites; Gametocidal all 4 plasmodia

2

Artemisinin

MOA:Unknown-Free Radicals; Maybe target PfATP6which is ER Ca2+ ATPase Uses: Blood Schizonticide all species

3

Chloroquine

MOA:Inhibits hemozoin formation in food vacuole Uses:Erythrocytic forms of all plasmodia

4

Quinine

MOA:Inhibits heme polymerization Uses: Blood schizonticide for all plasmodium and Babesiosis

5

Lariam: Mefloquine

MOA: Heme polymerzation inhibitor Uses: Erythrocytic forms of vivax and falciparum

6

Fansidar:Pyrimethamine-Sulfadoxine

MOA:Folate xynthesis inhibitor-pyrimethamine inhibits DHF-reductase Uses: Slow acting erythrocytic schizonticides malaria; toxoplasmosis

7

Atavaquone

MOA: Disrupts mitochondrial e- transport Uses: Any malaria infestation and Chemoprophylaxis

8

Proguanil

MOA: Folate synthesis Inhibitor; DHF-reductase inhibitor Uses: Erythrocytic Schizonticide

9

Tetra, Doxy, Clindamycin

MOA: Targets Apicoplast organelle in plasmodium Uses: Blood Schizonticide

10

Metronidazole, Tinidazole

MOA: May target DNA Uses: E. histolytica; Giardiasis; Trichominiasis

11

Iodoquinol

MOA: Unknown Uses: Kills trophozoites in GI Lumen

12

Pentamidine

MOA: Unknown - Accumulates in parasite Uses: W. African Trypanosomiasis, Visceral Leishmania; Pneumoncystosis

13

Nifurtimox

MOA: Generates ROS Uses: T. Cruzi

14

Miltefosine

MOA:Unknown Uses: Anti-leishmanial

15

Praziquantel

MOA:Disrupts Ca2+ homeostasis causing muscular contraction and spastic paralysis Uses: Cestodes and Trematodes

16

Beanzimidazoles (Mebendazole, Thiabendazole, Albendazole)

MOA: Binds to Tubulin and caps MTs; shortened from (-) end and don't grow Uses: Albendazole - cysticercosis, pinworms, hookworms, ascaris, trichuris, strongyloidiasis; Mebendzaole - pinworms, hookworms, ascaris, trichuris; Thiabendzaole - none, toxicity

17

Biethylcarbamazine

MOA: Unknown Uses: Filariasis and Loiasis; microfilariae killed fast and adults slowly

18

Ivermectin

MOA: Paralyzes microfilariae, intensifies GABA-mediated transmission of signals in peripheral nerves Uses: Strongyloidiaisis and Onchocerciasis

19

Pyrantel Pamoate

MOA: Neuromuscular blocking agent causing release of acetylcholine and inhibits cholinesterase Uses: Ascaris and Pinworms

20

Doxycycline (Parasites)

MOA: Kills Wolbachia bacteria Uses: Onchocercha die w/o wolbachia

21

Benzylpenicillin(Penicillin G)

MOA: _-lactam Abx inhibit transpeptidases that cross-link PG by acetylating Ser Residue on Transpeptidase Uses: G+ cocci; N. gonorrhoeae and H. flu

22

Methicillin

MOA: _-lactam Abx inhibit transpeptidases that cross-link PG by acetylating Ser Residue on Transpeptidase Uses: S. Aureus

23

Cephapirin

MOA: _-lactam Abx inhibit transpeptidases that cross-link PG by acetylating Ser Residue on Transpeptidase Uses: Same as penicillin

24

Imipenem

MOA: _-lactam Abx inhibit transpeptidases that cross-link PG by acetylating Ser Residue on Transpeptidase Uses: G+ and G- bacteria

25

Aztreonam

MOA: _-lactam Abx inhibit transpeptidases that cross-link PG by acetylating Ser Residue on Transpeptidase Uses: G- bacteria

26

Vancomycin

MOA: Binds to peptidyl side chain in PG precursor and inhibits transpeptidase activity Uses: G+ infections

27

Macrolides (Erythromycin)

MOA: Inhibit bacterial protein synthesis by binding reversibly to P site of ribosome inhibiting translocation from A to P-site Uses: G+ and some G-

28

Clindamycin

MOA: Binds to bacterial 50S ribosome in the P-site of ribosome and prevents protein synthesis Uses: Staph, Strep, anaerobic G- bacilli like Bacteroides and Fusobacterium

29

Tetracyclines

MOA: Bind to 30 S ribosomal subunit and inhibit bacterial protein synthesis blocking tRNA attachment in A site; terminates peptide growth Uses: Broad Spectrum; Chlamydia, Rickettsia, Brucellosis, Spirochetes, Anthrax, Plague, Tularemia, Legionella

30

Chloramphenicol

MOA: Binds 50S ribosomal subunit inhibits peptidyl transferase activity and blocks peptide bond formation Uses: Bact. Meningitis, Typhoid Fever, Rickettsia, bact. Conjunctivitis

31

Aminoglycoside

MOA: Block A site on ribosome, Impairs proofreading mechanism of ribosome so make nonsense proteins, Lead to ion leakage and disruption of cytoplasmic membrane Uses: Broad spectrum against G+ and G- but usually for G-

32

Dalfopristin

MOA: Inhibits peptidyl transferase to inhibit peptide bond formation Uses: Vanco resistant Enterococcus faecium, MRSA

33

Quinupristin

MOA: Binds to ribosomal Tunnel and blocks it Uses: Vanco resistant Enterococcus faecium, MRSA

34

Oxazolidinones

MOA:Prevents the formation of the ribosome by binding to the 50 S subnit Uses: Vanco resistant Enterococcus faecium, MRSA

35

Sulfonamides

MOA: Inhibit Dihydropteroate Synthase to inhibit folate synthesis Uses: Both G- and G+ bacteria

36

Quniolone

MOA: Inhibit DNA Gyrase and Religation by topoisomerase II Uses: UTIs, Prostatis, STDs, ETEC, S. pneumo

37

Tolnaftate

MOA: Inhibits Fungal Squalene Epoxidase and decreased ergosterol biosynthesis Uses:Dermatomycoses

38

Clotrimazole (Lotrimin)

MOA: Inhibits cytochrome p450 and thus inhibits lanosterol converstion to ergosterol Uses: Dermatomycoses

39

Griseofulvin

MOA: Disrupts mitotic spindle by binding polymerized MTs and inhibits mitosis Uses: Dermatomycoses; Onychomycosis

40

Amphotericin

MOA: Binds to ergosterol in fungal membranes and forms pores in membranes Uses: IV Tx for systemic infections

41

5-Fluorocytosine

MOA: Metabolized to 5-Fluorourcil and is incorporated into RNA Uses: Systemic Candida, Crypto neoformans meningitis

42

Echinocandins

MOA: Inhibits 1,3-_-glucan synthase for fungal walls Uses: Broad Spectrum Anti-fungal