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Pharm 2 > Exam 1 IBD > Flashcards

Exam 1 IBD Flashcards

1
Q

In UC, what layers are inflammed and is there continuous pattern of lesions?

A

Limited to mucosa and yes there is continuous pattern

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2
Q

UC or Crohns? What affects only the colon and rectum?

A

UC

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3
Q

UC or Crohns? Which one usually presents with diarrhea or bloody diarrhea?

A

UC

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4
Q

UC or Crohns? The course of dz is chronic, recurrent, and unpredictable.

A

UC

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5
Q

For how long do you need to have UC for before CA risk increases?

A

Increased risk of CA if UC >7-10years

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6
Q

UC or Crohns? Histology reveals mucosal changes consisting of loss of typical vascular pattern, granularity, friability, and ulceration.

A

UC

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7
Q

UC or Crohns? No diet improves or exacerbates it.

A

UC

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8
Q

UC or Crohns? Colectomy can cure it.

A

UC

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9
Q

UC or Crohns? Autoimmune pathophysiology

Can effect any segment of GI tract

Inflammation occurs throughout the full thickness of the bowel wall; skip pattern of involvement; strictures, fistulas, ulcers

A

Crohns

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10
Q

UC or Crohns? Sx of diarrhea and abd pain.

A

Crohns

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11
Q

How long does it take to respond to aminosalicylates?

A

2-3 weeks

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12
Q

What are the ADRs of aminosalicylates?

A
  1. Hypersensitivity rxns (rash, fever)-Do not use in pts with sulfa allergy
  2. Blood disorders (anemia, thrombocytopenia, granulocytopenia)
  3. Can impair folic acid absorption
  4. Idiosyncratic rxns (hepatocellular injury, agranulocytosis, lupus-like phenomena)
  5. Low sperm counts
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13
Q

Whats a risk of taking thiopurines?

A

4 fold increased risk of lymphoma

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14
Q

What are the contraindications for monoclonal antibodies?

A
  1. NYHA class III/IV heart failure

2. Hepatitis

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15
Q

What are the toxicities associated with infliximab?

A
  1. infections
  2. infusion reactions
  3. Delayed hypersensitivities
  4. Antibodies
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16
Q

Which drug has a black box warning and what is that warning?

A

Adalimumab-serious infection

Pharm 2 (3 decks)

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