Exam 2 Flashcards
2 reasons to use pre-emptive analgesia
decrease wind up and decrease use of iso and sevo
what is wind- up?
hyper excitability of central neurons due to constant bombardment of pain signals
define allodynia
pain caused by a stimulus that normally does not result in pain
define hyperalgesia
increase response to a painful stimulus
3 properties of NSAIDs
analgesia, anti-inflammatory, antipyretic
NSAIDs cause inhibition of
prostaglandins
prostaglandins cause(4)
vasodilation, sensitive pain receptors, granulation tissue, increase vascular permeability
COX-1 and COX-2 are important in the production of
prostaglandins
COX-1 is important for the production of
good prostaglandins
Good prostaglandins do what(3)
Maintain renal blood flow, production of gastric mucus, maintain platelet function
Cox-2 enzyme make prostaglandins that cause (2)
pain and inflammation
Example of COX-2 inhibitors
Carprofen, meloxicam, deracoxib`
injectable carporfen can give __ hours of analgesia
24 hours
NSAID side effects (4)
gastic ulcers, renal toxicity, impaired platelet function, hepatic damage
4 advantages of local anesthetics
few CV side effects, low cost, good pain control, min. pt recovery
What is splash block with local anesthetics
apply directly on nerves in surgery
With local anesthetics, cats are sensitive to
CRI of lidocaine
CRI does what in horse
decrease vap setting, increase GI motility
what is MLK
morphine, lidocaine, ketamine
MLK reduces inhalant requirement by
25-30%
injection into epidural space in what region
lumbosacral region
Local anesthetics epidural causes(2)
anesthesia and immobility
epidural with opioid good for
post op pain
Lidocaine, Bupivacine, Mepicaine lasts
1hr, 4-6hr, 2-3hr
Add what to lidocaine to increase duration
epinephrine
why is epinephrine added to locals?
causes vasoconstriction so local not absorbed as fast
epinephrine increases the duration of locals by
50%
epinephrine makes lido last up to
2 hours
epinephrine with locals is not indicated in _ because _
onychectomy, causes ishemia
Bupivacaine never goes_, can cause_
IV, cardiac arrest
Alpha-2 agonists aversive effects (4)
bradycardia, hypotension, heart blocks, decrease CO
Sedatives are not indicated for the
old and sick
Alpha-2 agonists, which last longer, sedation or analgesia
sedation
Microdoses of sedatives with other analgesics decrease inhalant anesth by __
20-30%
Ketamine is a
cyclohexaine
sedatives are reversed with
alpha-2-antiagonists
Ketamine is used as
induction agent or GA for short procedures
Ketamine is an antagonist to what receptor
NMDA
Gabapentin (Neurontin*) is a
analgesic and anticonvulsant
Gabapentin is used for
chronic and neuropathic pain
What is Amantadine
antiviral drug with analgesic effect
Amantadine is an antagonist to
NMDA
Why do we use PA drugs?(3)
Sedate, Pre-emptive analgesia, decrease amount of sevo/iso
Route of PA drugs
sub-q or IM
When are PA drugs given?
15-30 mins prior to induction
5 classifications of PA drugs
Anti-cholinergics, Tranquilizers, Sedatives, Opioids, Neuroleptanalgesia
Anticholinergics aka
parasympatholytics
Anticholinergics block
vagal nerve function
Anticholinergic effects
SLURED <3,
SLURED<3 R stands for
respiration, bronchodilation, leads to increase dead space can cause post-op hypoxia
What is antidote for organophosphate poisoning
anticholinergics
Anticholinergics may cause what in horses
colic, ileus
in horses anticholinergics are used to treat
brady cardia and and degree AV blocks
Benefits of glycol over atropine (2)
less likely to cause brady w/o increasing HR, lasts longer
contraindications of anticholinergics (3)
tachycardia, ileus/constipation, CHF/hyperthyroidism
Watch for what in cats when using anticholinergics
mucous plugs
Physical properties of Phenothiazines(2)
water soluble, yellow
Ace duration
2-8,24 hours