Exam 2: Miscellaneous Disorders of the Skin

Question 1

What is the pathology associated with vitamin A and zinc deficiencies?

Answer 1

Hyperkeratosis (follicular and/or epidermal) and acanthosis
Increased proliferation, disordered maturation
Compromised barrier function leads to secondary bacterial infections

Question 2

What causes skin fragility syndromes in cats?

Answer 2

Defect in collagen production, quality, or packaging
Hyperadrenocorticism, diabetes mellitus, hepatic disease

Question 3

What lesions are associated with short term solar injury?

Answer 3

Sunburn

Question 4

What lesions are associated with long term solar injury?

Answer 4

Degenerative changes in dermis (solar elastosis)
Pre-neoplastic changes of epidermis (actinic keratosis) –> can progress to squamous cell carcinoma, hemangioma/hemangiosarcoma

Question 5

What are the 3 types of photosensitization?

Answer 5

Type 1 (primary) = ingestion of preformed photodynamic substances
Type 2 = abnormal porphyrin metabolism
Type 3 = impaired liver function (inability to excrete phylloerythrin)

Question 6

What is the mechanism of photosensitizåtion?

Answer 6

Question 7

What type of photosensitization is most common in domestic species?

Answer 7

Type 3 = impaired liver function