Exam 3: Pancreas

Question 1

Gross/Microscopic Lesions: Acute Pancreatitis

Answer 1

Necrosis is the primary lesion - uncommon to have just acute inflammation
Red, swollen parenchyma (hemorrhage and edema)
Fat necrosis/saponification
Indistinct margins

Question 2

Gross/Microscopic Lesions: Chronic Pancreatitis

Answer 2

Gross: firm, small, nodular
Microscopic: atrophy, fibrosis, lymphocytic or lymphoplasmacytic inflammation

Question 3

What is the anatomical difference that predispose cats to chronic pancreatitis and triaditis?

Answer 3

Pancreatic duct and common bile duct have a common entry through duodenal papilla
Triaditis = combination of enteritis (IDB), pancreatitis, cholangitis or cholangiohepatitis

Question 4

Canine juvenile pancreatic atrophy

Answer 4

Cause of exocrine pancreatic insufficiency in young dogs
Complex genetic disorder, variation in inheritance
Advanced cases = small remnants of exocrine tissue with prominent ducts

Question 5

Clinical signs of EPI

Answer 5

Weight loss with normal appetite
Poor hair coat
Muscle atrophy
Pale, soft, voluminous ad malodorous feces

Question 6

Systemic consequences of acute pancreatic necrosis

Answer 6

Fibrosis/atrophy –> EPI
Cytokine storms –> systemic inflammatory response syndrome (SIRS) = DIC
Necrotizing panniculitis

Question 7

Exocrine nodular hyperplasia

Answer 7

Incidental
Pale nodules due to less zymogen granules

Question 8

What are the neoplasms of the exocrine pancreas?

Answer 8

Exocrine nodular hyperplasia
Adenoma = benign, discrete, encapsulated
Adenocarcinoma = tan/white, firm, multinodular, infiltrative, can have zymogen granules, metastasis common

Question 9

What are the neoplasms of the endocrine pancreas?

Answer 9

Islet cell tumors = insulinoma = excessive insulin = hypoglycemia