Exam 6 Arachidonic acid metabolites and NSAIDs Flashcards Preview

Skin/MSk > Exam 6 Arachidonic acid metabolites and NSAIDs > Flashcards

Flashcards in Exam 6 Arachidonic acid metabolites and NSAIDs Deck (24):
1

What does activation of prostacyclin (PGI2) and thromboxanes lead to?

Platelets, vasoconstriction, clotting

2

What does activationg of PGE2 lead to?

Pain, fever, vasodilation, uterine contraction

3

What is the mechanism of action of acetylsalicylic acid (aspirin)?

covalently binds to COX1 enzymes and irreversibly inhibits them

4

What is the mechanism of action of celecoxib?

Selective COX2 inhibitor

5

What is the advantage of celecoxib over aspirin?

decreases the risk of gastric ulceration

6

What is the disadvantage of celecoxib?

inhibits COX2 of endothelium in coronary and cerebral circulations (COX2 also decreases vasodilation)

7

Why have COX-2 inhibitors been withdrawn from the market?

They increase the risk of cardiovascular thrombosis

8

What is the mechanism of action of acetaminophen?

Blocks COX enzymes in the central nervous but not in the periphery

9

T/F: acetaminophen is antiinflammatory?

False

10

What does acetaminophen decrease?

fever and pain (good arthritis treatment)

11

What can an overdose of acetaminophen cause?

Hepatotoxicity

12

How does apirin affect platelets?

inhibits platelet's ability to produce thromboxane A2 for the duration of the platelet's life

13

What is low dose aspirin used for?

decreases thrombosis

14

What do prostaglandins do?

mediate many inflammatory effects of rheumatoid arthritis

15

What are drugs that block cyclooxygenase?

Ibuprofen, naproxen, celebrex

16

What is the action of glucocorticoids

transcriptional regulators that reduce numbers of lymphocytes, eosinophils, monocytes and basophils, but increase number of polymorphonuclear leukocytes, also synthesize proteins inhibiting Phospholipase A2

17

How do glucocorticoids act on white blood cells?

reduce the release of arachidonic acid and cytokines (IL1 and 6, TNF)

18

What are examples of corticosteroids?

dexamethasone, hydrocortisone, methylprednisone, prednisone

19

What are the toxic side effects of corticosteroids?

Osteoporosis, immune suppression, peptic ulcers, myopathy, cataracts, fluid accumulation and hyperglycemia

20

Are corticosteroids considered DMARDs for rheumatoid arthritis?

No

21

What do fish oils get turned into in the body?

PGE3, Thromboxane A3, PGI3

22

What is fish oil promoted as a treatment for?

rheumatoid arthritis

23

What does prostaglandin E2 cause?

edema, pain, redness, warmth

24

What is the target in reducing inflammatory symptoms of rheumatoid arthritis?

inhibiting prostaglandin synthesis