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Enodcrine > Exam One Hernandez Bone PINK SLIDES > Flashcards

Exam One Hernandez Bone PINK SLIDES Flashcards

1
Q

Etidronate

A

Didronel

  • 1st generation Bisphosphonates
  • ORAL AND INJECTABLE
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2
Q

Tiludronate

A

Skelid
1st generation bisphosphonates
ORAL

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3
Q

Pamidronate

A

Aredia
2nd generation
INJECTIBLE

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4
Q

Alendondrate

A

Binosto, Fosamax (+/- Vit D)
2nd Generation
ORAL

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5
Q

Risedronate

A

Actonel +/- calcium carbonate
3rd generation
ORAL

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6
Q

Ibandronate

A

Boniva
3rd Generation
ORAL AND INJECTABLE

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7
Q

Zoledronic Acid

A

Reclast, Zometa
3rd Generation
INJECTABLE

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8
Q

MOA of the 1st generation of Bisphophonates

A

Incorporate into ATP to create non-hydrolyzable ATP

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9
Q

MOA of the 2nd/3rd Generation of Bisphosphonates

A

Inhibition of FPPS on the mevalonate pathway

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10
Q

Which Bisphosphonates are ORALLY taken

A

ARTIE

Alendronate
Risenfronate
Tiludronate
Ibandronate
Etidronate
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11
Q

INJECTIBLE Bisphosphonates

A

EZIP

Etifronate
Zolendronic Acid
Ibandronate
Panindronate

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12
Q

rhPTH

A

NATPARA

PTH analog

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13
Q

Teriparatide

A

Forteo

PTH Analog

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14
Q

Regulation Hormone that decreases Plasma calcium concentration…

A

Calcitonin

-Stimulates osteoclasts

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15
Q

Dental Florides….

A

NaF

APF

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16
Q

NaF (Sodium Fluoride)

A

NEUTRAL
Safe for Dentures
CI in Renal Failure if administered Systemically

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17
Q

APF (Acidulated Phosphate Fluoride

A

ACIDIC

CI with porcelain or ceramic dentures

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18
Q

Vitamin D2

A

Ergocalciferol

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19
Q

Vitamin D3

A

Cholecalciferol

20
Q

Which Vit D is made from plants?

A

Ergocalciferol

VitD2

21
Q

Which Vit D is made from skin & UV ray?

A

Cholecalfiferol

VitD3

22
Q

Vit D3 is made from

A

Skin & UV ray

23
Q

Vit D2 is made from

A

Plants

24
Q

Where is Vit D2 & D3 metabolized?

A

Sequentially through the kidney and liver, to produce active Calcitriol

25
Q

Vitamin D drug interactions, MAJOR

A

Thiazides (HCTZ), Phosphates

26
Q

Minor Vit D drug interactions

A

Phenytoin
Aluminum/Magnesium products (Mylanta)
BAS

27
Q

What Vit D analog should you use if you have hepatic failure?

A

Calcifediol

-It bypasses the liver

28
Q

Vit D Analog for Renal Failure?

A

Doxecalciferol
Dihydrotachysterol
-It bypass the liver

29
Q

Wit D for Renal AND Hepatic Failure?

A

Calcitriol

Paracalcitol

30
Q

Most active form of Vit D Analog

A

Calcitriol*

31
Q

What is Calcium Carbonate used for?

A

Osteoporisis prophylaxis
CHRONIC Hypocalcemia
Hyperphosphatemia
Dyspepsia & GI hyperacidity

32
Q

Calcium Citrate used for..

A

Osteoporosis prophylaxis

Hypocalcemia

33
Q

Adverse effects for calcium carbonate

A

Hypophosphatemia

34
Q

Adverse effects for Calcium citrate

A

ACID rebound
gastric hypersecretion
hypercalcemia

35
Q

What is the ONLY RANKL Antibody?

A

Denosumab

Prolia, XGEVA

36
Q

MOA of Denosumab

A

Interupts the RANK to RANKL interaction so no osteoclast activation

37
Q

Which form of Denosumab is used for Osteoporois?

A

Prolia

38
Q

Which form of Denosumab is not used for Osteoporosis?

A

XGEVA (used for everything else)

39
Q

Natural Supplements for Bone Health

A

Cohosh
Ipriflavone
Xylitol
Strontium

40
Q

Nat Supplement used to treat osteoporosis, not to prevent?

A

Black Cohosh

41
Q

Soy derivative to PREVENT and TREAT osteoporosis, and relieve osteo pain.

A

Ipriflavone

42
Q

Important to prevent bacteria on teeth

A

Xylitol

43
Q

Mineral physically and chemically similar to calcium

A

Strontium

44
Q

For Dental Hypersensitivity

A

Strontium chloride hexahydrate

45
Q

Radiopharmaceutcal and for treatment of multiple osteoblastic bony metastatis or bone pain

A

Strontium-89

46
Q

Strontium Citrate

A

Nutritional Supplement

47
Q

NOT FDA Approved but is in EU for Osteop

A

Strontium Ranelate

Enodcrine (3 decks)

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