fluroquinolones

Question 1

mechanism of action

Answer 1

: inhibit bacterial DNA synthesis (bactericidal)

Gram(-) newer generations also gram (+)

Question 2

primary uses

Answer 2

: respiratory, GI, GU, some skin & soft tissue, used after exposure to Bacillus anthracis (anthrax)

Question 3

adverse effects

Answer 3

: nausea, vomiting, diarrhea, sleep disturbances, headache, dizziness
More serious: dysrhythmias, hepatotoxicity (particularly with moxifloxacin)
Avoid MVI & supplements, administer ~ 4H prior to antacids
Void in pregnancy & children (impact cartilage formation)
Tendinitis & Tendon rupture (Achilles) > 60 & corticosteroid therapy

Question 4

ciprofloxacin (Cipro)

Answer 4

Primary use: UTI, sinusitis, pneumonia, skin, bone, joints infections, prophylaxis of anthrax
Effective against some strains of MRSA
Well absorbed orally & QD or BID
Excreted Renally (hydration)