Fungal Infections Flashcards
1
Q
What are the 3 most common fungal infections in the UK?
A
Aspergillus fumigatus
Candida albicans
Cryptococcus neoformans
2
Q
Who is affected by opportunistic pathogen infections?
A
Impaired immune system
- Primary or secondary immunocompromised
- Malignancies or transplants
- Premature neonates
Chronic lung disease
- Asthma
- COPD
- CF
Affecting patients in ICU
3
Q
What are the classes of anti-fungals?
A
Inhibition of ergosterol synthesis = Azoles
Inhibition of glucan sythesis = Echinocandins
Inhibition of fungal DNA sythesis = Flucytosine
Amphotericin B = causes lysis of ergosterols
