Gastric

Question 1

Min lymph nodes gastric CA

Answer 1

16

Question 2

Yield of diagnostic laparoscopy gastric cancer

Answer 2

36%

Question 3

MAGIC trial

Answer 3

Periop ECF vs surgery alone
Gastric and Esophagus
OS improved
D2 rates low

Question 4

CROSS

Answer 4

Neoadj CRT (41.4Gy with Carbotaxol 5 weeks) vs surgery alone
Improved OS
Higher R0 rate (92 vs 69)
pCR 29% adeno, 49% squamous

Question 5

FLOT 4

Answer 5

FLOT (4+4) vs ECF (3+3)
Flot improves OS

Question 6

ARTIST 1

Answer 6

Adjuvant CRT vs chemo alone
No overall benefit
Node positive patients with intestinal type improved DFS

Question 7

ARTIST 2

Answer 7

S1 vs SOX vs SOX RT for node positive disease after D2 dissection
SOX and SOX RT better than S1 alone
SOX vs SOX RT no difference

Question 8

TOPGEAR

Answer 8

Periop chemo vs CRT (Prospect trial for gastric)
Gastric and EGJ

Question 8

INT 0116

Answer 8

Adjuvant CRT vs observation for node positive disease
Improves DFS
Very low rates of D2

Question 9

ESOPEC and NeoAegis

Answer 9

FLOT vs CROSS for esophageal and EGJ

Question 10

Genetic syndromes gastric cancer

Answer 10

Lynch
Peutz Jegher
Juvenile Polyposis syndrome
CDH 1

Question 11

GERCOR NEONIPIGA

Answer 11

Phase 2 Ipi/Nivo periop for resectable tumors
59% PCR

Question 12

Checkmate 577

Answer 12

Adjuvant Nivo in resected esophageal and GEJ tumors
Improved DFS