gastric - saliva, h.pylori

Question 1

how does human saliva secretion differ throughout the day?

Answer 1

in total 0.6-1L secretion a day but sleep, resting, eating the rates of secretion are different

Question 2

what is composition of saliva?

Answer 2

amylase
lipases
ribonucleases
IgG/M/E
EGF

Question 3

what cells secrete saliva?

Answer 3

secretory acinar cells which can secrete mucous, sera or both into the lumen/duct system

Question 4

how does the nervous system influence saliva secretion?

Answer 4

neuronal innervation uses reflex arch to control saliva secretion controllings its supression or activation

Question 5

what is function of saliva?

Answer 5

lubricate food, neutralise acids
forms food into bolus preventing entry into trachea
lysosome secretion contribute to anti-pathogen properties

Question 6

how is saliva secreted?

Answer 6

two stage theory in which the acinar cells secrete isotonic fluid

duct cells primary saliva and secrete electrolytes creating hypotonic saliva

Question 7

which electrolyte is key driver of saliva (and indeed any fluid) secretion?

Answer 7

chloride transcellular movement drives Na+ secretion and paracellular movement of water

also exchanged for bicarbonate secretion

Question 8

what is primary sjogrens syndrome? what are its symptoms?

Answer 8

autoimmune disorder where immune cell infiltration into salivary glands causing dry mouth

but can lead to severe renal, pulmonary complications too

Question 9

how can primary sjorens syndrome be diagnosed?

Answer 9

take a biopsy and identify evidence of immune cell infiltration/elevation
> B-cell in particular

Question 10

despite no cure for Primary sjorgens syndrome what is advantage of research?

Answer 10

saliva samples can be taken, non-invasive and easy to obtain

so used for studying biomarkers of disease and drug testing