GASTROINTESTINAL PHYSIOLOGY Flashcards

1
Q

What is digestion?

A

The processing of food.

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2
Q

What are the two types of digestion?

A

Mechanical (physical) and chemical.

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3
Q

What does the mechanical digestion involve?

A

Chewing, tearing, grinding, mixing, mashing of the food.

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4
Q

What does the chemical digestion involve?

A

Catabolic reactions, enzymatic hydrolisis (carbohydrates, protein, lipids)

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5
Q

What are the phases of digestion?

A

Ingestion, movement, digestion, absorption and further digestion.

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6
Q

What is the other name for GI tract?

A

alimentary canal

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7
Q

What is the GI tract?

A

Basically a tube within a tube, a direct link between organs.

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8
Q

What does the GI tract consist of?

A

mouth, oral cavity, pharynx, esophagus, stomach, duodenum, jejenum, ileum, caecum,
ascending colon, transverse colon, descending colon, sigmoid colon, rectum and anus.

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9
Q

Accessory structures which are not in the tube path are?

A

Organs. Teeth, tongue, salivary glands, liver, gall blader, pancreas.

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10
Q

What are the main functions of the mouth?

A

Breakdown of the food begins both chemically and mechanically and mixing food bolus with a lubricant.

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11
Q

Describe both ways (mechanical and chemical)

A

Mechanically-chewing
Chemically-enzymes from the saliva dissolve food

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12
Q

What is the lubricant in the mouth?

A

Saliva

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13
Q

What is the other name for deglutition?

A

Swallowing

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14
Q

What are the 3 stages of swallowing?

A

Voluntary stage, pharyngeal stage and esophageal stage

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15
Q

What happens in Voluntary stage

A

The food is pushed to the back of the mouth

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16
Q

Pharyngeal stage

A

Food is raised, it touches the soft palate.

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17
Q

Which the bones are important for the pharyngeal stage?

A

Larynx and hyoid bone

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18
Q

esophageal stage

A

Contraction of the pharyngeal muscles, open esophagus and start of peristalsis.

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19
Q

What are the three constriction of oesophagus(jednjak)?

A

Aortic arch, left primary bronchus, diaphragm

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20
Q

What is the oesophagus surrounded by?

A

The SNS plexus and blood vessels.

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21
Q

What are the functions of the oesophagus?

A

Secretes mucus and transports food.

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22
Q

Where is the stomach located?

A

On the left side, anterior (in front of) the spleen.

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23
Q

Mucous membrane consists of:

A

G cells, Goblet cells, Gastric pit (Oxyntic gland and Parietal cells) and Chief cells

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24
Q

What are each of their roles?

A
  • G cells – make gastrin
    – Goblet cells – make mucous
    – Gastric pit – Oxyntic gland – Parietal cells – Make HCl
    – Chief cells – Zymogenic cells * Pepsin
  • Gastric lipase
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25
Q

3 muscles layers of the stomach are?

A

Oblique, circular, longitudinal layer

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26
Q

The regions in the stomach are?

A

Cardiac sphincter, Fundus, antrum (pylorus) and the pyloric sphincter

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27
Q

What is Rugae?

A

The inner surface thrown into folds

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28
Q

At what pH do enzymes work best in the stomach?

A

At pH 1-2

29
Q

Functions of the stomach are?

A

Mix food
– Reservoir
– Start digestion of * Protein
* Nucleic acids * Fats
– Activates some enzymes
– Destroy some bacteria
– Makes intrinsic factor – B 12 absorption
– Destroys some bacteria

30
Q

What does the stomach absorb?

A

– Absorbs
* Alcohol
* Water
* Lipophilic acid
* B 12

31
Q

What are the gastric functions?

A

-Storage of food
- mixing and breakdown of food into chyme
- slowly emptying into duodenum for digestion and absorption

32
Q

The Gastric mucousa consists of ?

A

Cardia, fundus, body, antrum, pylorus

33
Q

Major cells that make up CORPUS are:

A
  1. surface epithelial, 2. chief (zymogen), 3. parietal, 4. enterochromaffin-like (ECL)
34
Q

What are each of their functions?

A
  1. mucus, HCO3-
  2. pepsinogen
  3. HCl, intrinsic factor
  4. histamine
35
Q

What are the major cells of the ANTRUM?

A

surface epithelial
chief (zymogen)
G-cells
D-cells

36
Q

What are the roles of G and D cells respectively?

A

Gastrin, somatostatin respectively

37
Q

What does the gastric juice contain?

A

HCl, pepsin, mucus, intrinsic factor

38
Q

HCl

A

conversion of pepsinogen to pepsine
- bacteriostatic effect

39
Q

mucus

A

protective coating, lubricant
- part of gastric mucosal barrier

39
Q

pepsin

A

protein digestion
- replaceable by pancreatic enzymes

39
Q

intrinsic factor

A

binds B12 vitamin, absorption in the ileum
- the only indispensable substance in gastric juice

40
Q

Small intestines- placement

A

Extends from pyloric sphincter to ileocecal valve

40
Q

Regions of small intestines are

A

Duodenum
– Jejenum
– Ileum

41
Q

Movements of small intestines include

A

Segmentation
– Peristalsis

42
Q

HISTOLOGY OF SMALL INTESTINES

A

Intestinal glands – Intestinal enzymes – Duodenal glands – Alkaline mucous
– Paneth cells – Lysozyme
– Microvilli
– Lacteals
– Plica circularis
– Smooth muscle
– Lymphatic tissue – GALT
– Vascular

43
Q

Small intestines absorb:

A

80% ingested water
– Electrolytes
– Vitamins
– Minerals
– Carbonates
* Active/facilitated transport
* Monosaccharides
– Proteins
* Di-/tripeptides
* Amino acids

– Lipids
* Monoglycerides
* Fatty acids
* Micelles
* Chylomicrons

44
Q

Small intestines secret digestive enzymes like:

A

– Peptidases
* Amino-
* Di-
* Tri-
– Sucrases
– Maltase
– Lactase
– Saccharidases
* Di-
* Tri-
– Lipase
– Nucleases

45
Q

What does the small intestine require?

A

pancreatic enzymes & bile to complete digestion

46
Q

What are the 4 functions of the GI tract?

A

Ingestion, digestion, absorption, egestion

47
Q

What is motility?

A

Mechanical breakdown of food, propulsion of food through gut

48
Q

Secretion?

A

Secretion of enzymes, water and ions

49
Q

Who controls the motility and secretion of GI tract?

A

Nervous system and hormones

50
Q

types of contraction are

A

Peristalsis, segmentation, tonic

51
Q

What does peristalsis do?

A

Propels the chyme from proximal to distal

52
Q

What does peristalsis consist of?

A

coordinated contractions and relaxation pushing the chyme ahead of it

53
Q

Tonic Contractions-explain

A

Contractions which can last for minutes or hours.
* Examples are the state of sphincters which are contracted so that chyme is not freely moving along, which means will move only under controlled condition.

54
Q

Why is segmentation important?

A

serve to mix the chyme with the various secretions of the intestines

55
Q

What will segmentation ensure happens?

A

ensures that the chyme comes into contact with the gut wall so that nutrients are absorbed

56
Q

Segmentation is most common where?

A

in the small intestine

57
Q

What are the functions of the large intestine?

A

Absorption of water
 Eliminates indigestible food from the
body as feces
 Does not participate in digestion of food
 Goblet cells produce mucus to act as a lubricant

57
Q

What are the structures of the large intestine?

A

Cecum, appendix, colon, rectum and anus

58
Q

Caecum?

A

saclike first part of the large intestine

59
Q

Appendix?

A

Crvuljak,
Hangs from the cecum

60
Q

What can happen to the appendix

A

Accumulated lymphatic tissue can become inflamed causing appendicitis

61
Q

What are the 4 parts of colon?

A

Ascending
 Transverse
 Descending
 S-shaped sigmoidal

62
Q

What happens in the large intestine, considering food breakdown and absorption ?

A

No digestive enzymes are produced Resident bacteria digest remaining
nutrients
- Produce some vitamin K and B
- Release gases
Water and vitamins K and B are absorbed
Remaining materials are eliminated via feces

63
Q

Propulsion in large intestine- explain

A

Sluggish peristalsis
Mass movements
Slow, powerful movements
Occur three to four times per day

64
Q

Defecation reflex?

A

Presence of feces in the rectum causes a defecation reflex
Internal anal sphincter is relaxed
Defecation occurs with relaxation of the voluntary (external) anal sphincter