General ANS knowledge Flashcards
SNS what spine level?
thoracolumbar: T1-L2-3
PSNS what spine level?
craniosacral: CN 3,7,9,10,
sacral 2-4
What activates ANS?
hypothalamus, brainstem, spinal cord, limbic system
PSNS dominate tone organs?
7
Heart (sa node) iris ciliary muscles GI tract Bladder salivary glands Genital tract(PSNS and SNS)
SNS dominate tone organs?
Arterioles
veins
sweat glands (cholinergic)
Genital tract (PSNS and SNS)
Define NT
Key targets for pharmacologic therapy
1. Synthesis of agent in presynaptic nerve terminal 2. Storage of agent in secretory vesicles 3. Regulated release of agent in the synaptic space 4. Presence of specific receptors for the agent on the postsynaptic membrane (e.g. agent mimics effects of nerve stimulation) 5. Means for termination of action of released agent (except NO)
Preganglionic SNS cell bodies are in
intermediolateral horn of spinal cord
Preganglionic SNS cell bodies are mostly myelinated ____ fibers that synapse on postganglionic neurons (mostly unmyelinated ___fibers) that then travel to ____ ______.
B
C
effector organs
Which fibers are easily blocked by locals ?
c fibers, postganglionic SNS neurons that run
to tissues innervated
Name 4 NT
ACH
EPI
NE
DA
Neuronal enzymatic catecholamine inactivation
MOA ( monoamine oxidase)
Liver enzymatic catecholamine inactivation
Catechol-O-methyltransferase
(COMT
Reuptake pump 1 =
80%
Uptake pump 2 is where?
extra neuronal
Vascular smooth muscle is single innervation?
T/F
T
