GI Pharmacology Flashcards Preview

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Flashcards in GI Pharmacology Deck (13):
1

A potent inhibitor of CYP450. Highly effective in suppressing nocturnal acid secretion but only modest effect on meal-stimulated secretion.

Cimetidine

2

Irreversibly blocks H+/K+ ATPAse in active gastric parietal cells. Side effects include malabsorption (of Vit B12, Ca, Fe, Zn), hypergastrinemia, strophic gastritis, and respiratory and symptoms enteric infections.

Omeprazole
SimD: lansoprazole, rabeprazole, pantoprazole, esomeprazole

3

A mucosal protective agent used for peptic ulcer disease and prevention of NSAID-induced gastric mucosal injury. Side effects include uterine cramping and miscarriage.

Misoprostol

4

A mucosal protective agent with side effects of black stools and darkening of the tongue. It reduces stool frequency and liquidity in infectious diarrhea.

Bismuth salicylate

5

Drug of choice for diabetic gastroparesis

Metoclopramide

6

A prokinetic agent that does not cross the BBB hence less toxic than other prokinetic agents.

Domperidone

7

A bulk-forming laxative used for constipation

Psyllium
SimD: methylcellulose, polycarbophil

8

A stool-softening laxative for constipation

Docusate
SimD: glycerine suppository, mineral oil

9

An osmotic laxative used for constipation and hepatic encephalopathy. Side effects include flatus, and electrolyte abnormalities.

Lactulose

SimD:
Polyethylene glycol (used in preparation for endoscopy)
Sorbitol
Magnesium oxide
Magnesium citrate
Sodium phosphate

10

A stimulant/cathartic laxative which causes melanosis coli, a benign disorder of colonic pigmentation

Senna

SimD: bisacodyl, aloe, cascara, castor oil

11

Used for nonspecific non-infectious diarrhea. Not used in children less than 4 years of age (due to their increased chance of having paralytic ileus).
Ileus can be reversed by administering __________________.

Diphenoxylate
SimD: loperamide, kaolin + pectin, colloidal bismuth

bethanecol

12

A 5-HT-3 receptor antagonist used for post-chemotherapy or post-operative vomiting

Ondansetron

13

An immunomodulator used for mild to moderate inflammatory bowel disease. NOTE: Not useful for treating flare-ups of disease. Side effects include bone marrow suppression and severe hypersensitivity reactions.

Mesalamine

SimD: olsalazine, sulfasalazine, balsalazide

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