Flashcards in GI Pharmacology Deck (13):
A potent inhibitor of CYP450. Highly effective in suppressing nocturnal acid secretion but only modest effect on meal-stimulated secretion.
Irreversibly blocks H+/K+ ATPAse in active gastric parietal cells. Side effects include malabsorption (of Vit B12, Ca, Fe, Zn), hypergastrinemia, strophic gastritis, and respiratory and symptoms enteric infections.
SimD: lansoprazole, rabeprazole, pantoprazole, esomeprazole
A mucosal protective agent used for peptic ulcer disease and prevention of NSAID-induced gastric mucosal injury. Side effects include uterine cramping and miscarriage.
A mucosal protective agent with side effects of black stools and darkening of the tongue. It reduces stool frequency and liquidity in infectious diarrhea.
Drug of choice for diabetic gastroparesis
A prokinetic agent that does not cross the BBB hence less toxic than other prokinetic agents.
A bulk-forming laxative used for constipation
SimD: methylcellulose, polycarbophil
A stool-softening laxative for constipation
SimD: glycerine suppository, mineral oil
An osmotic laxative used for constipation and hepatic encephalopathy. Side effects include flatus, and electrolyte abnormalities.
Polyethylene glycol (used in preparation for endoscopy)
A stimulant/cathartic laxative which causes melanosis coli, a benign disorder of colonic pigmentation
SimD: bisacodyl, aloe, cascara, castor oil
Used for nonspecific non-infectious diarrhea. Not used in children less than 4 years of age (due to their increased chance of having paralytic ileus).
Ileus can be reversed by administering __________________.
SimD: loperamide, kaolin + pectin, colloidal bismuth
A 5-HT-3 receptor antagonist used for post-chemotherapy or post-operative vomiting