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RENAL > [Glomerulonephritides] > Flashcards

[Glomerulonephritides] Flashcards

1
Q
A

Glomeruli

Nephrons

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2
Q
A

glomeruli damage

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3
Q
A

compensatory BP rise

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4
Q
A

Proteinuria
Haematuria

(mild –> nephrotic/macroscopic)

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5
Q
A

Hypertension
urine dipstick findings (2)
Renal function impaired

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6
Q
A

proteinuria (3.5g/day)

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7
Q
A

> 3.5g/day

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8
Q
A

normal or raised (mild)

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9
Q
A

normal or raised (mild)

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10
Q
A

normal/mild raised BP
normal/mild raised GFR
>3.5g/day protein

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11
Q
A

Moderate/severely raised BP
Moderate/severely raised GFR
Haematuria

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12
Q
A

Blood

mild to macro

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13
Q
A

Nephrotic

Nephritic syndrome

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14
Q
A

Mesangiocapillary GN

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15
Q
A

Mesangium

Basement membrane

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16
Q
A

Immune complex mediated

Complement mediated

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17
Q
A

classical

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18
Q
A

C

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19
Q
A

alternative

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20
Q
A

proliferated mesangium

thickened basement membrane

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21
Q
A

complement stains
light chains
Ig stains

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22
Q
A

ACEi/ARB

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23
Q
A

T

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24
Q
A

steroids

+-
cyclophosphamide

(immunosuppression)

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25
Q
A

Yes

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26
Q
A

rapid deterioration of renal function

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27
Q
A

mesangiocapillary GN

IgA nephropathy

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28
Q
A

IgA nephropathy

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29
Q
A

Haematuria

marked nephritic in fewer

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30
Q
A

relapsing and remitting (rapid recovery between attacks)

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31
Q
A

men

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32
Q
A

young

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33
Q
A

Western young man with attacks of haematuria

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34
Q
A

mesangial

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35
Q
A

mesangial proliferation

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36
Q
A

IgA

C3

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37
Q
A

ACEi/ARB

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38
Q
A

marked decline in renal function

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39
Q
A

Mesangiocapillary GN
Membranous GN
Minimal change
Focal segmental glomerularsclerosis

40
Q
A

Diabetes
Amyloid
SLE (class 5)
Hepatitis B and C

41
Q
A

B

C

42
Q
A

V (5)

43
Q
A

1 to 4

44
Q
A

abnormal protein in fibrillar form

45
Q
A

glomerular lesions

46
Q
A

antigen deposition on glomerulus
host reaction
immune complex deposition

47
Q
A 
SLE (1-4)
Vasculitis
Anti-GBM 
Cryoglobulinaemia
Post-streptococcal
48
Q
A

post-streptococcal

49
Q
A

antigen deposition on glomerulus
host reaction
immune complex deposition

50
Q
A

raised ASOT

raised C3

51
Q
A

Not required usually
95% recover with supportive Tx
Cure infection!

52
Q
A

anti-streptolysin O

(o = oxygen labile)

53
Q
A

An antibody against streptolysin O: an antigen produced by group A streps

54
Q
A

beta-haemolysis (RBC haemolysis full)

55
Q
A

a diffuse

56
Q
A

proteins which become insoluble at lower temperature

57
Q
A

Immunoglobulins

58
Q
A

Goodpastures disease

59
Q
A

type IV collagen

60
Q
A

IV (4)

61
Q
A

Renal glomerulus

Lung tissue

62
Q
A

pulmonary haemorrhage

63
Q
A

smokers

64
Q
A

nephritic/haematuria

65
Q
A

AKI (within days)

66
Q
A 
plasma exchange (removes antibodies)
\+
steroids
\+-
cyclophosphamide
67
Q
A

adds alkyl group to DNA - prevent synthesis

nitrogen mustard alkylating agent

68
Q
A

ANCA +ve

69
Q
A

anti-neutrophil cytoplasmic antibody

70
Q
A

neutrophils

71
Q
A

neutrophil

72
Q
A

Henloch-Schonlein purpura

73
Q
A

small vessel vasculitis

74
Q
A

small vessel vasculitis

75
Q
A

extensor surfaces

legs

76
Q
A

extensor surface purpura
polyarthritis (can be flitting)
Abdominal pain (GI bleed)
nephritis

77
Q
A

IgA depostion

identical to IgA nephropathy

78
Q
A

ACEi

steroids
+-
cyclophosphamide
if progressive renal dysfunction

79
Q
A 
anti-GBM 
anti-dsDNA (SLE)
ANA (SLE)
ANCA (vasculitis)
Anti-HCV (Hep C)
80
Q
A

HBsAg (Hep B surface antigen)

81
Q
A

Multiple myeloma

it is a light chain

82
Q
A

renal biopsy

no need in Post-strep

83
Q
A

1g/day

84
Q
A

<75

85
Q
A

ACEi/ARB

86
Q
A

GN!

87
Q
A

days

88
Q
A

Crescents affecting most glomeruli

89
Q
A

3

90
Q
A

Immune complex (47%)
Pauci-immuni (50%)
Anti-GBM (3%)

91
Q
A

IgA
HSP
Post-strep
SLE

92
Q
A

pauci immune

93
Q
A

T

94
Q
A

pulmonary haemorrhage

95
Q
A

yes

96
Q
A

IV steroids
+
cyclophosphamide
+- plasma exhange

RENAL (14 decks)

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