Glomerulonephritis

Question 1

This dz presents in pt 1-3 wks after a bout of strep throat

Answer 1

post-infectious GN

Question 2

this is the most common cause of recurrent hematuria

Answer 2

IgA Nephropathy (Berger dz)

Question 3

This dz will present with an elevated ASO titer

Answer 3

post-infectious GN

Question 4

pt presents with flank pain, hematuria, cola-colored urine ,and RBC casts

Answer 4

post-infectious GN

Question 5

Which area of the kidney does IgA GN deposit itself

Answer 5

mesangium

Question 6

this pt presents with hematuria & cola-colored urine 1-2 days post-UR illness. May also have some vessel vasculitis

Answer 6

IgA nephropathy

Question 7

How would you treat IgA nephropathy

Answer 7

based on proteinuria

Question 8

pt presents with elevated C-ANCA in their serum, following an URI

Answer 8

Wegener’s

Question 9

This pt presents with elevated eosinophils in their serum, typical nephritic like symptoms accompany (hematuria, edema, mild proteinuria, HTN, inflammation/infection, decreased GFR, oliguria

Answer 9

Churg Strauss

Question 10

this may be a localized variant of Henoch-Schonlein purpura

Answer 10

IgA nephropathy aka Berger Dz

Question 11

This set of nephritic disorders presents with small-vessel vasculitis. Renal bx shows necrotizing lesions & crescents

Answer 11

Pauci-Immune (ANCA)

Question 12

this pt presents with anti-GBM antibodies in the serum, has had a recent URI with hemopytis & usual nephritic symtoms…

Answer 12

Good Pasture

Question 13

Why would an ANCA test alone not help you distinguish btw nephritic symptoms…

Answer 13

It can be positive in Wegener’s (C-ANCA) but also in Good Pasture’s as well…

Question 14

what serum test would you want to order to confirm a suspected case of good pasture’s

Answer 14

a serum test looking for Anti-GBM antibodies….

Question 15

This classic case presents with nephritic type symptoms (inflammation, HTN, mild edema/proteinuria, oliguria, decreased GFR) and **Hearing loss

Answer 15

Alports

Question 16

this glomerulonephritis disorder is most common cause of proteinuria in kids

Answer 16

minimal change dz

Question 17

This is the most common cause of nephrotic GN in adults

Answer 17

membranous GN

Question 18

this nephrotic type GN (proteinuria>3.5) hypoalbuminemia, hyperlipidemia, hypercoagulable) is often a secondary cause which results from protein deposits that clump in tissue

Answer 18

amyloidosis

Question 19

this disease which is classified as nephrotic also presents with some nephritic type symptoms…

Answer 19

focal and segmental GN

Question 20

This pt presents with the classic nephrotic symptoms and upon UA-oval fat bodies are found along with proteinuria and edema

Answer 20

minimal change dz

Question 21

Why would you want to differentiate btw Focal & Segmental GN vs. minimal change dz in kids

Answer 21

Focal can progress to ESRD 6-8 years which is rare in minimal change…

Question 22

this nephrotic disease is notoriously for being highly variable, with a prognosis of 1/3remission, 1/3relapse, 1/3 ESRD

Answer 22

membranous GN

Question 23

How would you manage/tx an adult with membranous GN

Answer 23

Low-salt diet, ACE inhibitor, & transplant if necessary

Question 24

How would the urine differ between a nephritic vs. nephrotic disorder

Answer 24

nephritic is more active (dysmorphic RBC, casts) vs. nephrotic more bland, frothy