Gout

Question 1

NSAIDs

Naproxen, Celecoxib

Answer 1

Inhibit production of prostaglandins & urate crystal phagocytosis

Question 2

Prednisolone

Answer 2

Glucocorticoids = reduce inflammation

Question 3

Colchicine

Relieve pain & inflammation in acute within 24-36 hours

Answer 3

1. Bind to tubulin
2. Prevent tubulin polymerisation into microtubules
3. Inhibits leukocyte migration & phagocytosis
4. Inhibit leukotriene B4 & prostaglandin production

Question 4

Allupurinol

Uric acid synthesis inhibitor

Answer 4

Anti-hyperuremic agents
Decrease uric acid production
Xanthine Oxidase inhibitor so hypoxanthine not converted to xanthine to uric acod
= Analogue of purines

Question 5

Probenecid

Uricosoric agent

Answer 5

1. Inhibit proximal tubule anion transport
2. Inhibits uric acid re-absorption
3. Increases uric acid excretion