Gram Negative Aerobic, Non-Carbohydrate Fermenters

Question 1

Pseudomonas aeruginosa

Answer 1

Burns (skin/skeletal)

Meningitis (nervous/muscle)

Endocarditis (lymph)

Cystic fibrosis (respiratory)

Question 2

Francisella tularensis

Answer 2

Ulcers (skin/skeletal)

Conjunctivitis (nervous/muscle)

Pneumonia

Question 3

Bordetella pertussis

Answer 3

Pertussis (respirotry)

Question 4

Pseudomonas aeruginosa

Answer 4

Tm: HAIs - ventilators, i.v. solutions, anesthesia equipment
CAIs - hot tubs and swimming pools; washcloths, sponges
burn and cystic fibrosis patients
septicemia → endocarditis, meningitis, pneumonia
grape-like odor, pyocyanin produces “blue pus”
Tx: abx

Question 5

Tularemia (Francisella tularensis)

Answer 5

Tularemia
Tm: direct contact (mammalian zoonosis), arthropod vectors, inhalation
resists freezing; viable for weeks in water and soil; easily aerosolized
ID = 10-50 cells
intracellular pathogen, spreads in macrophages
ulcerative skin lesions, headache, backache, fever, chills, extreme weakness,
lymphadenopathy, conjunctivitis
Tx: abx

Question 6

Pertussis

Answer 6

Tm: respiratory droplets/aerosols; 0–4-year-olds
capsule bind to mucociliary escalator; pertussis toxin destroys it
mucus buildup and airway blockage
1. Catarrhal stage: nasal drainage, congestion, sneezing, coughing
2. Paroxysmal stage: sudden, violent coughing attack, followed by deep inhalation
(“whoop”)
Tx: DTaP vaccine, abx