H pylori and gastric disease

Question 1

What is dyspepsia

Answer 1

• Describes a group of symptos

Upper abdominal discomfort, reterosternal pain, anorexia, nausea, pain vomiting, fullness, early satiey

Question 2

What are causes of Upper GI dyspepsia

Answer 2

• Peptic ulcer
• Gastritis
• ## Gastric cancer

Question 3

What are the ALARM features?

Answer 3

• Anorexia
• Lose of weight
• Anemia - Iron deficiency
• Recent onset > 55
• Melena/Heamatemesis
• Swallowing problems - dysphagia

Question 4

When would you do and upper GI if the patient didn’t present with alarm features

Answer 4

• Test for h-pylori infection

Question 5

Describe the Helicobacter pylori bacteria

Question 6

Where can H pylori colonise

Answer 6

• The stomach and only the stomach

- Resides in the surface mucousal layer and does not penetrate the epithelial layer

Question 7

What are the potential clinical outcomes of H.pylori disease

Answer 7

• Gastric ulcers
• Peptic ulcers
• Gastritis
• Gastric cancer

Question 8

What is the diagnosis for H.pylori?

Answer 8

• Non-Invasive: 13/14c Urea breath test
• Serology IgG antigen test
• Invasive: Endoscopy

Question 9

What is the more invasive therapy to diagnose H.pylori infection?

Answer 9

• Endoscopy

- Rapid slide urease test (CLO)

Question 10

What are the three different cause’s of gastritis?

Answer 10

• Autoimmune (Parietal cells)
• Bacterial (H pylori)
• Chemical (bile/NSAID’s)

Question 11

What are the main causes of peptic ulcers, who does it effect more?

Answer 11

H pylroi, Men more than women