HC 1 Flashcards

1
Q

welke tracti zijn ingangen voor ziekteverwekkers

A

tractus respiratorius
tractus digestivus
reproductieve organen

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2
Q

mechanische barrieres van lichaam

A

epitheelcellen
luchtflow
beweging cilia
tranen
nasale cilia

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3
Q

chemische barriere van lichaam

A

zuren
lage pH
enzymen
surfactant
enzymen in tranen en speeksel
antibacteriele peptide

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4
Q

microbiologische barriere van lichaam

A

normale microbioom stimuleert epitheel om antimicrobiele peptide te secreteren (niet pathogene bacterien competeren met pathogene bacterien)

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5
Q

volgorde immuunrespons

A

innate immuun respons
early induced innate response
adaptieve immuunrespons

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6
Q

innate immuunrespons

A

herkenning + verwijdering infectieuze agent

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7
Q

early induced innate response

A

recruteren cellen
herkenning PAMP
activatie effectorcellen
inflammatie
verwijdering

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8
Q

adaptieve immuunrespons

A

transport antigen naar lymfoide organen
herkenning door B-/T-cellen
clonale expansie
differentiatie
verwijdering

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9
Q

hoe ontstaat acute inflammatie

A

toxische schade
trauma
infectie
post-ischemische schade
auto-immuunreactie

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10
Q

symptomen acute inflammatie (2 fases)

A

fase 1: rubor (roodheid), calor (warmte)
fase 2: tumor (zwelling), dolor (pijn), function loss

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11
Q

5 R’s bij infectie reactie

A

recognition
recruitment (of inflammatory leuko’s)
removal (of initial stimulus)
regulation
restoration (of homeostasis)

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12
Q

waar bestaat de innate immuunrespons uit

A

snelle reactie
granulocyten
macrofagen
dendritische cellen

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13
Q

adaptieve immuunrespons

A

langzame reactie
B- (humorale) en T-cellen (cellulaire)

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14
Q

hoe zorgen T-cellen voor variatie in receptoren

A

D, J, C, V-herschikking

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15
Q

MHC klasse 2 met? en MHC klasse 1 met?

A

MHC 1 (=HLA1) met CD8+
MHC 2 (=HLA2) met CD4+

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16
Q

functie APC cel

A

activatie
survival
differentiatie (T-cel door cytokine prod.)

17
Q

lymfeklieren opbouw
medulla
follikels
paracortex
sinuses
reticulaire cellen
folliculaire DC

A

medulla en follikels: antilichaam productie
paracortex: b-cel, cytotoxicity
sinuses: scavenging
paracortex: Ag-presentatie
reticulaire cellen: structuur, snelle Ag transport, faciliteert celmigratie
folliculaire DC: Ag presentatie aan B-cellen

18
Q

3 routes van lymph node entry

A

conduit (oplosbare Ag, 15-30min)
cell-bound (trabeculaire sinus, 18-24u)
lymfocyten in bloedbaan (hoog endotheliale venule, HEV)

19
Q

5 stappen van extravasatie

A

entry
rolling
integrine activatie
adhesive
diapedesis

20
Q
A