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HD 2015 > HD Exam 1 > Flashcards

HD Exam 1 Flashcards

1
Q

IL-7

A

Nurse cells within thymus.

Transforms stem cells –> common lymphoid progenitor cells.

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2
Q

CD28

A

on T cell.
Co-stimularoty molecule -associates with APCs
B7-CD48

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3
Q

B7 (aka CD80 and CD68)

A

on APCs.

Co-stimulatory molecule- associates with T Cell B7-CD48

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4
Q

CD40Ligand

A

on T cell.

Binds CD40 on APCs surface –>express co-stimulatory molecule or T cell production of cytokines

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5
Q

CD40

A

On APCs.

Binds CD40L on Tcell

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6
Q

MHC Class I

where??

A

on surface of ALL nucleated cells (not RBCs)

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7
Q

MHC Class I

do??

A

Binds viral antigen w/in ER of host (w/ 2 conserved anchor residues)
Displays antigen on cell surface
Interacts w/ CD8+ Killer T cell

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8
Q

MHC Class II

where??

A

on surface of APCs: dendritic cell, B cell, monocytes (immature macrophages)

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9
Q

MHC Class II

do??

A

Binds endocytosed antigen (w/ 4 conserved anchor residues)
Displays antigen on cell surface
Interacts w/ CD4+ Helper T cell

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10
Q

LFA-1 (CD11a)

A

On T cell.

Adhesion molecule that binds ICAM-1 during immuno synapse and migration out of circulation

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11
Q

ICAM-1

A

on APCs and endothelial cells (along high end post-capillary venules)
Adhesion molecule that binds LFA-1 on T cell during immune synapse

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12
Q

CD34+

A

on surface of stem cells (in ALL hematopoietic) in bone marrow.

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13
Q

CD7+

A

on thymocytes at junction bw differentiation into a T cell or NK cell

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14
Q

CD56+

A 
on NKT (Natural Killer T cell) 
unique to NKT
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15
Q

CD1+

A

on pre-T cells.

commits the T cell to T lineage

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16
Q

CD25+

A

on T reg cells

unique to T regs

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17
Q

FOXN1

A

transcription factor in 3rd pharyngeal pouch endoderm

Stimulates maturation of thymic epithelium

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18
Q

AIRE

A

transcription factor in mTEC (medullary thyme epithelial cells)
Stimulate production of antigen in mTEC that mirror antigen seen in endocrine organ
makes sure T cells are not reactive to other self-antigen not present in thymus

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19
Q

FOXP3

A

transcription factor in Treg cells

stimulates production of Treg cells from CD4+ T cells

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20
Q

TGF-β

transforming growth factor β

A

released from APCs
Induce at periphery: CD4+ T cell –> Treg cell
In presence of IL-23 and IL6 –> Th17 respone

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21
Q

IL-12

A

Released from APCs (dendritic cells) in response to antigen presentation
Required to stimulate Th1 (TMMI) response from naive CD4+ Tcells

22
Q

IL-18

A

Released from APCs (dendritic cells) in response to antigen presentation
Enhances IL-12 properties in generating Th1 (TMMI) response

23
Q

T-bet

A

Transcription factor on Th1 cells.

seen on transition of CD4+ Th0 –>Th1

24
Q

IL-2

A

Released from Th1 cells
Upregulates Th1 response
Required for Treg proliferation and survival

25
Q

IFN-γ

(interferon γ) release from??

A 
released from: 
Th1 committed cells
NKT cell
γ/δ T cell
CD8+ T cells
26
Q

IFN-γ

function??

A

Amplifies TMMI
Activates macrophages and homes effector cells to site of infection
Down regulates Th2 and Th17
Up-regulates production of pro-inflammatory cytokines

27
Q

IL-21

A

Produced by Th1 and Th2 cells
Upregulates CD8+ Killer T cell activity
In presence with IL-4 (TH2), IL-21 stimulates B cell proliferation, differentiation, and survival (when it’s NOT TMMI )

28
Q

IL-1

A

Produced by activated macrophages and keratinocytes
Pro-inflammatory
IL1 and IL6 inc body them by affecting hypothalamus
Promote neutrophil migration from bone marrow
Promote marrow stimulation growth factor–>Inc leukocyte production
Inc Th1 response to IL-2

29
Q

IL-1ra

A

endogenous antagonist of IL-1

30
Q

IL-6

A

Produced by active macrophages and Th2
Pro-inflammatory
Redundant with IL-1
Inc cell receptiveness to IL-2
Growth and differentiation effects on B ell
Important to bone calcium metabolism by inducing RANKL expression
IL-6 w/ IL-23 and TGH-β –>Th-17 response

31
Q

IL-8

A

Produced by macrophages
Pro-inflammatory
stimulates Neutrophil proliferation, mobilization and recruitment

32
Q

TNF-α

A

produced by activated macrophages
Pro inflammatory: causes vasodilation and MHC expression, Pontent macrophage activator, Induces RANKL in bone remodeling
Non-inflammatory: regulates apoptosis to maintain immuno homeostasis

33
Q

INF-α

A

cytokine released from viral infected cells
Stimulate NK cells
prohibited by IL-10

34
Q

INF-β

A

cytokine released from viral infected cells
Stimulate NK cell
tx for MS

35
Q

IL-4

A

released from Th2 and APC (dendritic cell)

Stimulates Th2 response
Principal B cell growth initiation cytokin
Drives immune response that require antibody formation
Down regulates macrophage and dendritic cell functions
Inhibits RANKL expression in bone remodeling

36
Q

GATA-3

A

transcription factor in Th2 cells

unique to Th2

37
Q

IL-5

A

produced by Th2

stimulate B cell growth and isotope conversion

38
Q

IL-10

A

produced by Th2

stimulate B cell growth and isotope conversion
Supresses Th1 response
Used as primary cytokine in Tr1 immunosuppressive response
Inhibits RANKL expression in bone remodeling
IL-10 w/ TGF-β (and NO IL-6) –>Treg cells produced in periphery

39
Q

IL-13

A

produced by Th2 cells

down regulates macrophages and dendritic cell functions
Crucial of IgE response

40
Q

IL-23

A

produced by APCs

IL-23 w/ IL-6 and TGF-β –> Th17 response

41
Q

ROR

A

Transcription factor in Th17-cells

Stimulated by IL-23 to covert naive Th0 –> Th17

42
Q

IL-17

A

released from Th17

Committed cells
Potent neutrophil recruiter
Induces RANKL in bone remodeling

43
Q

CD278

A

on T follicular helper cells

on ThF responsible for antigen specific B cell response
ONLY found in B follicles of lymphoid tissue

44
Q

AID

A

enzyme on B cells

Activates isotope conversation (switch) by cleaving genes (for IgM and IgD) bw VDJ segment and new constant region of heavy chain segment (IgA or IgG)

45
Q

CD59

A

Host cell surface

Prevent membrane attach complex formation

46
Q

IL-27

A

Release from APC

Induces conversion of Th0 to Tr1 (a type of immunosuppressive Tcell - not FOXP3 expressing)

47
Q

CTLA-4

A

on T cell

Acts as off switch for T cell immune response
Competes with CD28 for B7 binding
Recruits signaling molecules than inhibit TCR (T cell receptor) signaling

48
Q

CD20

A

on B cell

unique to B cells

49
Q

TAP-1 and TAP-2

Transporter Associated antigen Processing

A

in ALL nucleated cells - during MHC class I antigen processing

Bring viral protein fragments from proteasome to ER

50
Q

ERAAP

Endoplasmic Reticulum Aminopeptidase associated w/ Antigen Processing

A

in ALL nucleated cells -during MHC class I antigen processing

Trap the viral DNA inside ER

HD 2015 (1 decks)

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