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HEMATOLOGY > HEMA PLATINGS > Flashcards

HEMA PLATINGS Flashcards

1
Q

EPO prevents natural cell degeneration of most immature red cell by:
a. averting the mitochondrial release of cytochrome C by activating the
STAT pathway”
b. stimulate the early release of more mature nucleated red cell thus
preventing the continuous interaction of the Fas and FasL of red cell
progenitor cells
c. Both A and B
d. Neither A nor B

A

Both A and B are correct

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1
Q

Which of the following statement is false?
a. Pyrenocyte is characterized by a red cell with extruded nuclear material
b. The metarubricyte is the first progenitor red cell that exhibits reddish
blue cytoplasm.
c. Both A and B are correct
d. Neither A nor B are correct

A

Both A and B are correct

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2
Q

Normally mature red cell should have:
a. more than 3 um diameter of red cell pallor.
b. an average cell size of 7.5 um.
c. Both A and B
d. Neither A nor 8

A

an average cell size of 7.5 um.

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3
Q

True about orthochromatophilic erythroblast:
a. Commonly has 1:2 N:C ratio
b. The most mature progenitor red cell with nucleus
c. Both A and B are correct
d. Neither A nor 8 are correct

A

Both A and B are correct

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4
Q

Which is True?
a. Approximately 3-5% of the bone marrow hematopoietic cells are
metamyelocyte Neutrophils.
b. Around % of the bone marrow hematopoietic cells are metamyelocyte
basophil.
c. Both A and B
d. Neither A nor B

A

Both A and B are correct

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5
Q

The Hematopoietic stem cells (HSC) is activated by internal signals/stimulators such as:
a. KIT Ligand and NOTCH 2
b. GATA 2 genes and FLT3 Ligand
c. Both A and B are correct
d. Neither A nor B are correct

A

Neither A nor B are correct

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6
Q

False about myeloblast:
a. Normally it comprises the 1-3% of the bone marrow hematopoietic
cells.
b. It is the earliest stage that synthesizes azurophilic granules or nonspecific granules.
c. Both A and B
d. Neither A nor B

A

Both A and B

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7
Q

Which is a character of progenitor cells in monopoiesis?
a. The monoblast can be fully distinguished from Lymphoblast with
their CD markers.
b. The monocyte formed may stay in the blood approximately for more
than 21 days.
c.Both A and B
d. Neither A nor B

A

The monoblast can be fully distinguished from Lymphoblast with their CD markers.

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8
Q

Character of Lymphoblast:
a. With 2-4 visible nucleoli.
b. Has a basophilic cytoplasm.
c. Both A and B
d. Neither A nor B

A

Both A and B

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9
Q

False about mesoblastic period of hematopoiesis
a. Usually begins on the 19th-20th week of pregnancy
b. Commonly ends before the 2nd month of pregnancy
c. Both A and B are correct
d. Neither A nor B are correct

A

Neither A nor B are correct

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10
Q

Which is a character of Lymphocyte production?
a. The final lymphocyte development may occur on different lymphoid
organs.
b. Antigen-dependent lymphocyte differentiation occurs on secondary
lymphoid organs.
c. Both A and B
d. Neither A nor B

A

Both A and B

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11
Q

Which of the statement/s is/are false?
a. The HSC may randomly retain as stem cell for storage pool.
b. The asymmetric division of HSC’s is characterized by one for renewal
and one for differentiation.
c. Both A and B are correct
d. Neither A nor B are correct

A

Neither A nor B are correct

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12
Q

Which of the following is True about basophilic erythroblast?
a. It usually divides twice thus producing 8 rubricyte.
b. Late stage of it may exhibit 1:l ratio with murky grayish-red-blue
cytoplasm
c. Both A and B are correct
d. Neither A nor B are correct

A

It usually divides twice thus producing 8 rubricyte.

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13
Q

True about Myeloid period of hematopoiesis:
a. There is a gradual increase of Hgb Al in the later part of the 3rd
trimester
b. Usually begins approximately between the 4th and 5th month of
pregnancy
c. Both A and B are correct
d. Neither A nor B are correct

A

Both A and B are correct

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14
Q

Which is False?
a. Neutrophil has a half-life of 7 days and may migrate on tissues and
resides in it for several days more.
b. All Lymphocytes released form the bone marrow is considered as the
end stage cell.
c. Both A and B
d. Neither A nor B

A

All Lymphocytes released form the bone marrow is considered as the end stage cell.

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15
Q

Match the appropriate characteristic for each item. -
reticulocyte
-rubriblast
-rubriblast
-rubricyte

-polychromatophilic erythrocyte
-with basophilic cytoplasm and visible nucleoli
-the Hgb in cytoplasm causing an initial reddish cytoplasmic
appearance
-the cytoplasm is basophilic and with 6:1 N:C ratio

A

reticulocyte-polychromatophilic erythrocyte

rubriblast-with basophilic cytoplasm and visible nucleoli

rubriblast-the Hgb in cytoplasm causing an initial reddish cytoplasmic appearance

rubricyte-the cytoplasm is basophilic and with 6:1 N:C
ratio

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16
Q

Match the appropriate character on each immature
hematopoietic cells?
-Rubriblast
-metarubricyte
-Hematopoietic stem cell

-the immediate precursor of basophilic erytrhoblast
-the nucleus exhibits karyorhexis
-positive with CD 117 and 34

A

Rubriblast-positive with CD 117 and 34
metarubricyte-the nucleus exhibits karyorhexis

Hematopoietic stem cell-the immediate precursor of basophilic erytrhoblast

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17
Q

Match the hematopoietic cell with its appropriate characteristic
-Neutrophil
-Eosinophil
-Basophil

-with 3-5 nuclear lobulation and lilac cytoplasmic granules
-the main content of its granule is capable of killing larva
-its granules is dark blue in color

A

Neutrophil-with 3-5 nuclear lobulation and lilac cytoplasmic granules

Eosinophil- the main content of its granule is capable of killing larva

Basophil-its granules is dark blue in color

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18
Q

Match the N:C ratio for each immature red cells. -Basophilic
erythroblast
-Metarubricyte
-Rubriblast

-6:1
-1:2
-8:1

A

Basophilic erythroblast-6:1
Metarubricyte-1:2
Rubriblast-8:1

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19
Q

The last stage of immature progenitor red cell that is capable of nuclear division: (Give the RUBRI nomenclature)

A

rubricyte

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20
Q

Match the proginator cell with correct characteristic -Has remnants of ribosomes and mithochondria
-With Red-Blue-Grayish cytoplasmic color
-Has 1:1 ratio

-late rubricyte
-diffusely basophilic erythroblast
-orthochromatophilic erythroblast

A

Has remnants of ribosomes and mithochondria-diffusely
basophilic erythroblast

With Red-Blue-Grayish cytoplasmic colororthochromatophilic erythroblast

Has 1:1 ratio-late rubricyte

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21
Q

with no cytoplasmic granules but with visible nucleoli

A

Myeloblast

22
Q

it is the where the primary granules first
appear

A

Promyelocyte

23
Q

-the nuclear indentation is more than half of the diameter of the nucleus

A

band cell

24
Q

-it is also known as the juvenile cell

A

metamyelocyte

25
Q

-it is where the secondary granules first appear

A

myelocyte

26
Q

A type of hematopoiesis model where the stem cells fate is randomly dictated.

A

STOCHASTIC

27
Q

It is defined as the difficulty to aspirate the bone marrow fluid:

A

DRY TAP

28
Q

A condition which is characterized by the presence of NRBC and immature WBC on Blood Smears:

A

BONE MARROW DAMAGE

29
Q

-to differentiate Granulocytic form nongranulocytic leukemi

A

Esterase Stain

30
Q

to confirm Chronic Granulomatous Disease

A

NBT

31
Q

-to stain Iron in tissue sections

A

Pearl’s stain

32
Q

used to confirm Acute Myelogenous
leukemia

A

Peroxidase stain

33
Q

used to assess Hairy cell leukemia

A

TRAP stain

34
Q

Report the M:E ratio. Myeloid % is 40. Erythroid % is 60
a. 1:1.5
b. none of these
c. 1.5:1
d. 1:2

A

a. 1:1.5

35
Q

A reverse M:E ratio is commonly seen on which of the following conditions:
a. Leukemoid reaction
b. Eryhtroleukemia
c. Erythroblastic reaction
d. CML

A

Eryhtroleukemia

36
Q

The “Antigen-dependent” Lymphocyte differentiation took place on secondary lymphoid organs like the lymph nodes
a. True
b. False

A

TRUE

37
Q

Which is an ideal fixative for bone marrow biopsy?
a. Zenker’s
b. 40% formalin
c. Both A and B
d. Neither A nor B

A

Zenker’s

38
Q

Which of the following has Hypercellular Bone marrow?
a. Myelofibrosis
b. Aplastic anemia
c. Both A and B
d. Neither A nor B

A

d. Neither A nor B

39
Q

The following conditions will definitely have a hypocellular bone marrow;
a. Polycythemia vera
b. Leukemia
c. Both A and B
d. Neither A nor B

A

Neither A nor B

40
Q

Stain used to diagnose chronic granulomatous disease
a. NBT
b. TRAP
c. Both A and B
d. Neither A nor B

A

a. NBT

41
Q

Stain used to diagnose Hairy cell leukemia
a. Esterase stain
b. LAP
c. Both A and B
d. Neither A nor B

A

Neither A nor B

42
Q

The Positive selection of the T-lymphocyte occurs on what organ
a. spleen
b. Thymus
c. Both A and B
d. Neither A nor B

A

b. Thymus

43
Q

Which of the following will have a hypocellular bone marrow
a. Leukemoid reaction
b. Leukemia
c. Both A and B
d. Neither A nor B

A

Neither A nor B

44
Q

Special stain to differentiate Myeloid leukemia to lymphoid leukemia
a. Peroxidase
b. Sudan black B
c. Both A and B
d. Neither A nor B

A

Both A and B

45
Q

T helper cell has CD:
a. 19
b. 56
c. Both A and B
d. Neither A nor B

A

Neither A nor B

46
Q

Number of Cells observed during Bone Marrow differential count.
a. 500
b. 300
c. Both A and B
d. Neither A nor B

A

c. Both A and B

47
Q

If the Fat and perivascular layer is 8% and the buffy coat layer is 2% the bone marrow

a. Nomo-cellular
b. Hypocellular
c. Both A and B
d. Neither A nor Bow is said to be:

A

b. Hypocellular

48
Q

Special Stain used to differentiate Leukemia from Leukemoid reaction:
a. Pearls stain
b. NBT
c. Both A and B
d. Neither A nor B

A

Neither A nor B

49
Q

Normal marrow cell that morphologically confused with plasma cell.
a. Osteoblast
b. Mast cell
c. Both A and B
d. Neither A nor B

A

Osteoblast

50
Q

Which of the following will give an decrease M/E layer?
a. Polycythemia vera
b. Fanconi’s anemia
c. Both A and B
d. Neither A nor B

A

Fanconi’s anemia

51
Q

Normal reference range of buffy coat layer of the aspirated
bone marrow
a. 1-5%
b. 5-8%
c. Both A and B
d. Neither A nor B

A

5-8%

52
Q
A

HEMATOLOGY (5 decks)

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