Heme/Onc Flashcards
1
Q
Liver disease and cystic fibrosis results in a prolonged (PT / PTT)?
A
PT
2
Q
Half life of factor VII?
A
very short
~6 hours
- Can become deficient in liver disease and prolong PT (extrinsic pathway)
3
Q
Cryoprecipitate contains _
A
fibrinogen
fibronectin
VWF
Factors VIII and XIII
4
Q
DIC is a form of consumptive coagulopath that results in prolonged (PT / PTT)?
A
Both
5
Q
Warfarin inhibits __, which serves which purpose?
A
gamma-glutamyl carboxylase
- this enzyme allows carboxylation of Vit K dep clotting factors (II, VII, IX, X, prot C and S)
6
Q
What is unique about pts with lupus anticoagulant and their PT/PTT?
A
Lupus anticoagulant binds w/ the phospholipid that activates aPTT and results in a prolonged aPTT (clotting is taking longer to occur).
- BUT, Pts w/ lupus anticoagulant are actually PROTHROMBOTIC
