Hemostasis Defects II

Question 1

PT is prolonged with

Answer 1

Factor II, VII, V, X, fibrinogen deficiencies, vitamin K deficiency, liver disease or patient on warfarin

Question 2

If protime is more prolonged than PTT:

Answer 2

liver disease, vit K deficiency, warfarin or rat poison

Question 3

Prolonged PTT indicates:

Answer 3

Hemophilia (deficiency in factor VIII, IX, or XI), acquired hemophilia, severe von Willebrand disease, heparin in sample (an anticoagulant), fibrin split products. Also can indicated Factor XII deficiency or lupus anticoagulant (both non-bleeding disorders).

Question 4

If PTT is relatively more prolonged than PT:

Answer 4

Disseminated intravascular coagulation (DIC)

Question 5

Prolonged bleeding time indicates:

Answer 5

vascular disorders (thrombocytopenia, DIC, etc) and von Willebrand Disease–not by other coagulation factors such as haemophilia

Question 6

_______ and _______ can prolong bleeding time significantly

Answer 6

Aspirin and other cyclooxygenase inhibitors