hGH Flashcards
What is hGH?
Human growth hormone
What is hGH produced by?
Produced by somatotropic cells of the anterior lobe
function of hGH
stimulate most cells but target bone and skeletal muscle and promote protein synthesis
hGH stimulates what in the body?
Liver, skeletal muscle, bone and cartilage to produce insulin like growth factors
what is the direct action of hGH?
promotes lipolysis and inhibits glucose uptake
what are hGH metabolic effects?
- Enhances in vivo protein synthesis – augments body proteins
- Decreased lipid stores
- Conserves CHO
what does hGH promote?
Promotes protein deposition in tissues
what does hGH increase?
- Amino acid transporters
- RNA translation and therefore protein synthesis
- Nuclear Transcription of DNA to form RNA
what does hGH decrease?
- Protein catabolism (degradation) – break down of proteins
why is increasing RNA translation good by hGH?
Increases protein synthesis in the cytoplasm
what are the roles of proteins?
- Energy metabolism
- Synthesis and breakdown of biomolecules
- Storage and transport of biomolecules
- Muscle contraction
- Cellular communication (signal transduction)
what is needed for hGH to increase nuclear transcription?
sufficient energy, AA, vitamin and growth factors required
why is increased nuclear transcription important?
increased RNA = increased protein synthesis
what is the most somatotrophic effect on hGH?
increasing nuclear transcription
