Histology Flashcards

1
Q

What two systems relate to the circulatory system?

A
  1. The cardiovascular system (blood vascular system)

2. The lymphatic vascular system

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2
Q

Where is the majority of blood in the body found?

A

In the peripheral veins

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3
Q

What are the 3 basic layers on the blood vessels?

A
  1. Inner layer
  2. Middle layer
  3. Outer layer
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4
Q

What does the Inner layer of the blood vessel consist of?

A

Tunica intima, a single layer of squamous epithelial cells (endothelial cells) support by a basal lamina and a thin layer of connective tissue

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5
Q

What does the middle layer of the blood vessel consist of?

A

Tunica media, made predominantly of smooth muscle

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6
Q

What does the outer layer of the blood vessel consist of?

A

Tunica adventitia, made of supporting connective tissue

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7
Q

What separates the tunica intima from the tunica media?

A

A layer of elastic tissue called the internal elastic membrane

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8
Q

What separates the tunica media from the tunica adventitia?

A

A layer of elastic tissue called the external elastic membrane

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9
Q

What is the vasa vasorum?

A

The vascular supply that large vessels possess

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10
Q

What are capillaries composed of?

A

Endothelial cells and a basal lamina

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11
Q

What are arterioles composed of?

A

Only have one or two layers of smooth muscle in their tunica media and almost no adventitia

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12
Q

What are pericytes?

A

Connective tissue cells that have contractile properties in capillaries. Found at intervals just outside the basal lamina

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13
Q

What are the three types of capillaries?

A
  1. Continuous capillaries
  2. Fenestrated capillaries
  3. Sinosoidal or discontinuous capillaries
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14
Q

Where are continuous capillaries found?

A

In muscle, connective tissue, lung, skin and nerve. The most common

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15
Q

Where are fenestrated capillaries found?

A

Mucosa of the gut, endocrine glands, glomeruli of the kidney. Have pores in the walls

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16
Q

Where are sinusoidal/fenestrated capillaries found?

A

Liver, spleen and bone marrow.

Lack a basal lamina and have large gaps for macromolecules and sometimes cells to pass through

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17
Q

What helps control the flow through the network of capillaries?

A

Precapillary sphincters

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18
Q

Where do capillaries networks drain into?

A

Post-capillary venules

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19
Q

What are post-capillary venules?

A

Endothelial cell-lined, and contain a thin layer of connective tissue and occasional pericytes

20
Q

What is a venule?

A

A post-capillary venule that has begun to acquire intermittent smooth muscle cells in a tunica media layer

21
Q

Describe the layers in a vein

A

Tunica intima
Relatively thin but continuous tunica media ( consisting of a few layers of smooth muscle)
Large veins e.g. vena cava have thick tunica adventitia

22
Q

What do most small to medium sized veins have?

A

Valves that are inward extensions of the tunica intima

23
Q

What are the 3 layers of the heart

A
  1. Endocardium - inner layer
  2. Myocardium - middle layer
  3. Epicardium - outer layer
24
Q

What does the endocardium do?

A

Lines the entire surface of the heart, including the valves

25
Q

Describe the structure of the endocardium

A
Endothelium
Basal lamina
Thin layer of collagen fibres
Layer of deep denser connective tissue
Some areas there's a subendocardium of loose connective tissue containing small blood vessels and nerves and the branches of the impulse conducting system
26
Q

Describe the structure of the myocardium

A

Bundles and layers of contractile cardiac muscle fibres

Individual muscle fibres surrounded by delicate, collagenous connective tissue with a rich network of capillaries

27
Q

What is the purpose of intercalated discs?

A

Found in the myocardium passing along fibres at irregular intervals
Aid to attach cells and allow spread of electrical activity

28
Q

Describe the structure of the epicardium

A

A single layer of flattened epithelium called mesothelium on the outer layer of the heart
Basal lamina
Fibroelastic connective tissue and in some places, adipose tissue

29
Q

What are the two parts of the pericardium?

A
  1. Fibrous pericardium

2. Serous pericardium

30
Q

Describe the fibrous pericardium

A

A sac of tough fibrocollagenous connective tissue

31
Q

What are the two types of serous pericardium?

A
  1. Parietal serous pericardium

2. Visceral serous pericardium

32
Q

Where is parietal serous pericardium found?

A

Lines the inner surface of the fibrous pericardium

33
Q

Where is the visceral serous pericardium found?

A

Covers the surface of the heart

34
Q

What is the serous pericardium composed of?

A

A layer of simple squamous epithelium (mesothelium) backed by a basal lamina and connective tissue

35
Q

What supports the valves and provides attachment for cardiac muscle fibres?

A

The fibrous ‘skeleton’ formed by thick bands of fibrous connective tissue around the heart valves, between the atria and between the ventricles

36
Q

Are there blood vessels in the heart valves?

A

No

37
Q

Describe the structure of heart valves

A

An outer endothelial layer with basal lamina
Layer of collagen and elastin fibres
Core of dense connective tissue, called the lamina fibres that is continuous with the fibrous skeleton

38
Q

What anchors the leaflets of the valves to the papillary muscles in the wall of the ventricle?

A

Collagenous strands called the chordae tendineae which merge with the lamina fibrosa

39
Q

What is the lamina fibrosa?

A

The core of the heart valves and is dense irregular connective tissue that is continuous with the fibrous skeleton of the heart

40
Q

What covers both sides of the heart valve?

A

Endothelium

41
Q

What are the 3 types of cardiac muscle cells?

A
  1. Contractile cells (99%)
  2. Pacemaker cells
  3. Conducting cells
42
Q

What do the Purkinje fibres do?

A

They distribute the excitatory activity such that ventricular contraction generally occurs from inferior to superior

43
Q

What does the lymph vascular system consist of?

A

Lymphatic vessels that drain tissue fluid, eventually returning it to veins in the base of the neck

44
Q

What is institial fluid (lymph) made of?

A

Ions, lipids, proteins and occasional cells

45
Q

What produces flow in the lymphatic vessels?

A

Hydrostatic pressure in the tissue and compression of the vessels by voluntary muscle, combined with valves in the vessels