Homeostatis Flashcards
Homeostatis control
Stimulus-change receptors-detect afferent-input cns-control centre efferent-output response-homeostatic control
THE MAINTENANCE OF A RELATIVELY STABLE INTERNAL ENVIRONMENT THROUGH THE NERVOUS AND ENDOCRINE SYSTSEM
Positive Feedback
Reinforces change
platelets
Negative Feedback
Resists change
temperature
Autoregulation-intrinsic
Localised Tissue
Extrinsic
Nervous system- specific rapid response
Endocrine (hormones)- widespread long lasting slow response
Complications
infection/injury/abnormality which effects are so severe that homeostatic mechanism cant compensate for them
Newborn
vulnerable to significant changes in homeostasis due to immaturity of the : immune system renal function endocrine system thermoregulation
Don’t possess all the necessary antibodies, lymphacytes, memory cells, muscle bulk, subcutaneous fat.
Ageing
Degeneration over regeneration
less responsive to hormones
decreased efficiency of heart and circulatory system
loss of neurones and neurotransmittors
Calcium
found in bone, blood and extracellular fluid
critical for muscle and nerve function
regulated by endocrine system
Hormones controlling calcium
calcitriol growth hormone thyroxine sex hormones parathyroid hormone calcitonin
increase blood calcium levels
Low calcium plasma levels
decteded by parathyroid glands secrete parathyroid hormone (PTH)
PTH:
Bone response- osteoclasts stimulation to breakdowm stored calcium ions from bone to blood
Intestinal response- rate of of intestinal absorption increases
Kidney reponse- retain calcium ions- calcium conserved decrease calcium loss in urine
decrease blood calcium levels
High calcium plasma levels
Parafollicular cells in the throyoid glands secrete calcitonin
calcitoin:
Bone response- osteoclasts inhibition, osteoblasts build bone calcium is stored in bone matrix
Intestinal Response- rate of of intestinal absorption decreases- calcium absorbed slowly
Kidney response- allow calcium loss- excrection- increase calcium in urine
Osteoporosis
insufficent calcium intake- hypercalcaemia- stimulating PTH release and osteoclast activity
sex hormones deficiency- increase osteoclast activity
vitamin C deficiency- reduced calcitirol activity- absorbs calcium from digestive tract
Inactivity- bone remodelling increasing osteoclast activity
Smoking-tobacco toxin to osteoblast
Illness- endocrine disorders, medication
Management
weight bearing
muscle strength and balance
lifestyle
diet
Blood pressure
Cardiac output x peripheral resistance
- heart rate
- stroke volume
- resistance to flow
- blood volume