Hormones Flashcards

1
Q

what is affinity

A

the ability of a drug to bind to its receptor

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2
Q

what is efficacy

A

the ability of a drug to activate its receptor

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3
Q

what is competitive antagonism

A

when the antagonist will act to prevent the agonist from binding

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4
Q

how does endocrine hormones get to its target

A

through the bloodstream

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5
Q

what does the endocrine do

A

they synthesize and secrete hormones and pass them directly into the bloodstream

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6
Q

do endocrine cells contain ducts

A

no

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7
Q

do exocrine contain ducts

A

yes

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8
Q

what causes hypercortisolism

A

when the adrenal gland produces excess cortisol
or excess ACTH from the pituitary tumor

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9
Q

what is hypercortisolism also known as

A

Cushing’s disease

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10
Q

what does Cushing’s disease do

A

hyperglycemia - too much glucose in blood

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11
Q

what is hypercorticolism

A

when the adrenal gland produces too little cortisol

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12
Q

what parts make up the adrenal gland

A

medulla and cortex

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13
Q

what does the adrenal gland do

A

mediates rapid stress response, electrolyte balance and minor role in development of sexual characteristics

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14
Q

physiological effects of the adrenal gland

A

fat breakdown, glycogen breakdown, increased cardiac function, increased ventilation

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15
Q

what is the function of the zona reticularis

A

responsible for the production of androgens

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16
Q

what is the function of the zona fasciculata

A

responsible for producing glucocorticoids

17
Q

what is the function of the zona glomerulosa

A

responsible for the production of aldosterone

18
Q

steroid hormones are synthesised from …

A

cholesterol

19
Q

cortisol is an example of what

A

glucocorticoids

20
Q

what steroid hormones does the cortex produce

A

cortisol, aldosterone and endogens

21
Q

what is gluconeogenesis

A

the synthesis of glucose from non-carbohydrate sources

22
Q

what does cortisol do

A

it is a long-term mediator of stress response

23
Q

what is the metabolic function of cortisol

A

mobilises energy to cope with, adapt to or escape from stress

24
Q

where does the conversion of low affinity androgens to the high affinity androgens take place

A

in non-adrenal tissue

25
Q

aldosterone is an example of what

A

mineralocorticoids

26
Q

what do mineralocorticoids do

A

regulate minerals

27
Q

mineralocorticoids receptors are what type of receptors

A

steroid receptors

28
Q

what does angiotensin II do

A

binds to receptors on the zona glomerulosa and stimulates the conversion of cholesterol to aldosterone and other mineralocorticoids

29
Q

what enzyme is used to convert angiotensin I into angiotensin II

A

ACE (angiotensin converting enzyme)

30
Q

what does IGF-1 stimulates

A

it stimulates chondrocyte proliferation

31
Q

what does GH stimulate

A

cell maturation and IGF-1 production

32
Q

how does TH help GH

A

stimulates GH receptor expression

33
Q
A