Hot topics

Question 1

What is normal CMRO2?

Answer 1

It’s the cerebral metabolic rate, and it is normally 3.5 mL/100g/min or 50 mL of o2/min in resting state

Question 2

Increase in CMR also increases ____

Answer 2

CBF. Mechanism not understood.

Question 3

Who uses more O2? Gray or white matter?

Answer 3

Gray

Question 4

___ and ___ are most sensitive to brain injury

Answer 4

Hippocampus and cerebellum

Question 5

Cerebral function is dependent on a continuous supply of :

Answer 5

Glucose.

Question 6

Is insulin needed to get glucose into the brain?

Answer 6

No. crosses BBB on its own via facilitated diffusion

Question 7

If the brain can’t get glucose it’ll use what?

Answer 7

Lactate, and then ketones during times of starvation

Question 8

What do Volatiles do to CMRO2?

Answer 8

Dose dependent decrease in CMR

Question 9

N20 on CMRO2?

Answer 9

Increases

Question 10

isoelectric EEG can cause a ___% reduction in CMRo2

Answer 10

`60%

Question 11

IV anesthetics and CMR:

Answer 11

all decrease it EXCEPT ketamine!

Question 12

Hypothermia and CMRo2

Answer 12

for each degree decrease in temp, there’s a 6-7%drop in CMRO2