HYDROPHILIC AND LIPOPHILIC DRUGS

Question 1

HYDROPHILIC AGENTS

Answer 1

Beta-lactams
Aminoglycosides
Glycopeptides
Daptomycin
Polymyxins

Question 2

HYDROPHILIC AGENTS

1) Small volume of distribution -»

Answer 2

Poor tissue penetration

Question 3

HYDROPHILIC AGENTS

2) Renal elittiination

Answer 3

Drug accumulation and side effects (e.g„ nephrotoxicity, seizures) can occur if not dose adjusted

Question 4

HYDROPHILIC AGENTS

3) Low/ Intracellular concentrations -»

Answer 4

Not active against atypical (intracellular) pathogens

Question 5

HYDROPHILIC AGENTS

4) increased clearance and/or distribution In sepsis - »

Answer 5

Consider loading doses and aggressive dosing in sepsis

Question 6

HYDROPHILIC AGENTS

5) Poor-moderate bioavailabilitv ->

Answer 6

Not used PO or IV:PO ratio is not 1:1

Question 7

LIPOPHILIC AGENTS

Answer 7

Quinolone
Macrolides
Rifampin
Linezolid
Tetracyclines

Question 8

LIPOPHILIC AGENTS

Large volume of distribution

Answer 8

Poor tissue penetration

Question 9

LIPOPHILIC AGENTS

Hepatic metabolism

Answer 9

potential for hepatotoxicity and drug-drug Interactions

Question 10

LIPOPHILIC AGENTS

Achieve intracellular concentration

Answer 10

active against atypical

Question 11

LIPOPHILIC AGENTS

clearance and distribution Is changed minimally in sepsis

Answer 11

Dose adjustments generally not needed in sepsis

Question 12

LIPOPHILIC AGENTS

excellent bioavailability

Answer 12

IV:PO is often 1:1