Hyperlipidemia

Question 1

Hyperlipidemia causes

Answer 1

Primary-genetic, abnormalities leading to increased production of cholesterol or decreased clearance of cholesterol

Secondary-environmental, factors including medications, disease conditions, diets high in fat & cholesterol, obesity, smoking

Question 2

Plasma lipids

Answer 2

Cholesterol, triglycerides, phospholipids

Question 3

LDL

Answer 3

Low density lipoproteins, produced in liver & peripheral cells

60-75% of total cholesterol, directly related to the development of atherosclerosis

BAD cholesterol

Question 4

HDL

Answer 4

High density lipoproteins, produced in liver & intestine

Functions to remove LDL & triglycerides transport to liver for metabolism (reverse cholesterol transport)

GOOD cholesterol

Question 5

Antioxidants

Answer 5

Such as vitamin E, prevent the oxidation of LDL & may be beneficial in preventing CHD

Oxidized LDL is more atherogenic then non oxidized LDL

Question 6

Primary symptom of atherosclerosis

Answer 6

Chest pain (angina)

Due to compromised blood flow in vessel lumen

Question 7

Primary prevention

Answer 7

Management of patients w/no evidence of CHD or risk equivalents

Question 8

Secondary prevention

Answer 8

Management of patients w/CHD or risk equivalents