Hypothalamic control of food intake Flashcards
What is the BMI that puts someone in the class of obesity?
30
What are some examples of health risk associated with obesity?
Type 2 diabetes, cardiovascular disease, sleep-breathing abnormalities, gallstones, menstrual irregularity, cancer
What regulates the homeostatic system?
Hypothalamus and brainstem
What regulates the hedonic system?
Ventral Tegmental area
Which system depends on pleasure sensation?
Hedonic
Which hypothalamic regions regulate food intake?
3rd ventricle, dorsomedial nucleus, ventromedial nucleus, arcuate nucleus
Parabiosis experiments consist of surgical union of ________ individuals, so that they share a common circulation of the blood
Two
What are the three parabiosis experiments?
Ob/ob + normal - ob/ob reduced
Db/db + normal - normal loses weight and dies of starvation
Db/db + ob/ob - ob/ob loses weight and dies
While leptin-deficient subjects respond well to leptin, obesity is associated with ___________ circulating leptin
Increased
Which substance restores normal body mass in leptin-deficient mice?
Leptin
What is hyperleptinemia?
Lack of response to exogenous leptin
Which hypothalamic regions in the arcuate nucleus are related to increased food intake and decreased food intake?
POMC associated with decreased food intake
NPY/AgRP associated with increased food intake
Leptin is linked to _________ while ghrelin is linked to __________
Satiety; hunger
Cre is a protein that leads to neurons that lack ___________
LeptinR
A lack of leptin receptors on either POMC neurons or AgRP neurons or VMH neurons shows….
Mild obesity
