Immune Deficiencies

Question 1

Bruton’s agammaglobulinemia

Answer 1

B-Cell Disorder

Question 2

Hyper-IgM Syndrome

Answer 2

B-Cell Disorder

Question 3

Selective Ig Deficiency

Answer 3

B-Cell Disorder. IgA is the most common.

Question 4

Common Variable Immunodeficiency (CVID)

Answer 4

B-Cell Disorder

Question 5

Thymic aplasia

Answer 5

T-Cell Disorder. DiGeorge Syndrome

Question 6

IL-12 Receptor Deficiency

Answer 6

T-Cell Disorder

Question 7

Hyper-IgE Syndrome

Answer 7

T-Cell Disorder. Job’s Syndrome.

Question 8

Chronic mucocutaneous candidiasis

Answer 8

T-Cell Disorder. Oral Thrush will be present.

Question 9

Severe Combined Immunodeficiency (SCID)

Answer 9

B & T Cell Disorder. Bubble Boy Syndrome

Question 10

Ataxia-Telangiectasia

Answer 10

B & T Cell Disorder

Question 11

Wiskott-Aldrich Syndrome

Answer 11

B & T Cell Disorder

Question 12

Leukocyte Adhesion Deficiency (type 1)

Answer 12

Phagocyte Dysfunction

Question 13

Chediak-Higashi Syndrome

Answer 13

Phagocyte Dysfunction

Question 14

Chronic Granulomatous Disease

Answer 14

Phagocyte Dysfunction

Question 15

C1INH Deficiency (C1 inhibitor)

Answer 15

Angioedema due to uncontrolled C1 activation. Lasts about 3 days, non-itchy tissue swelling.

Question 16

C3 Deficiency

Answer 16

Bacterial infection and higher incidence of SLE and RA.

Question 17

C5-C9 Deficiencies

Answer 17

Increased risk of Neisseria meningitidis infections.