Immune Responses

Question 1

Type of immunity acquired through receiving preformed antibodies with rapid onset and short span of antibodies.

Answer 1

Passive immunity

Question 2

IgA in breastmilk, maternal IgG crossing placenta, humanized monoclonoal antibody are examples of what type of immunity?

Answer 2

Passive immunity

Question 3

Type of immunity that is acquired through exposure to foreign antigens with slow onset but conferns long lasting protection.

Answer 3

Active immunity

Question 4

Natural infections, vaccines and toxoids are examples of what type of immunity?

Answer 4

Active immunity

Question 5

Secreted by macrophages that causes fever, acute inflammation.
Activates endothelium to express adhesion molecules.
Induces chemokine secretion to recruit WBCs
Osteoclast-activating factor

Answer 5

Interleukin-1

Question 6

Secreted by macrophages that causes fever and stimulates production of acute-phase proteins

Answer 6

Interleukin-6

Question 7

Major chemotactic factor for neutrophils that is secreted by macrophages

Answer 7

Interleukin-8

Question 8

Cytokine that is secreted by macrophages that induce differentiation of T cells into Th1 cells. Also activates NK cells

Answer 8

Interleukin-12

Question 9

Cytokine that is secreted by macrophages that activates endothelium and causes WBC recruitment and vascular leak. Also causes cachexia in malignancy

Answer 9

Tumor necrosis factor-alpha

Question 10

Cytokine secreted by T cells that stimulate growth of helper, cytotoxic, and regulatory T cells, and NK cells

Answer 10

Interleukin-2

Question 11

Cytokine secreted by T cells that support growth and differentiation of bone marrow stem cells.

Answer 11

Interleukin-3

Question 12

Cytokine from Th1 cells that is secreted by NK cells and T cells in response to antigen or IL-12 from macrophages.
Stimulates macrophages to kill phagocytosed pathogens.
Inhibits differentiation of Th2 cells

Answer 12

Interferon-gamma

Question 13

Cytokine from Th2 cells that induces differentiation of T cells into Th2 cells. Also promotes growth of B cells.
Enhances class switching to IgE and IgG

Answer 13

Interleukin-4

Question 14

Cytokine from Th2 cells that promote growth and differentiation of B cells. Also enhances class switching to IgA.
Stimulates growth and differentiation of eosinophils

Answer 14

Interleukin-5

Question 15

Attenuates inflammatory response. Decrease expression of MHC II and Th1 cytokines.
Inhibits activates macrophages and dendritic cells.
Secreted by regulatory T cells

Answer 15

Interleukin-10

Question 16

Cytokines that mediate fever and sepsis

Answer 16

IL-1, IL-6, TNF-alpha