Immunology Flashcards
List some “physical barriers” the eye has to prevent disease
Blink reflex
Chemical properties of eye surface
Small size
How do tears physically protect against disease?
Flushing/washout debris
Mucin layer is anti-adhesive - reduces risk of pathogen adherence to eye
What chemical components of tears help protect against disease?
Lysozyme Lactoferrin/transferrin Complement Antibacterial lipids Secretory IgA
What is the only part of the eye that has dendritic cells + lymphatic drainage?
Conjunctiva
The cornea and sclera are avascular. True/False?
True
How does the fact the cornea and sclera are avascular with no MALT help in protecting the eye?
Downregulates immune response
What is sympathetic ophthalmia?
Rare bilateral granulomatous uveitis due to trauma/surgery to one eye
What are the primary inflammatory mediators in sympathetic ophthalmia?
T cells
In sympathetic ophthalmia, the injured eye is known as the excited/sympathetic eye and the fellow eye is known as the excited/sympathetic eye
In sympathetic ophthalmia, the injured eye is known as the excited eye and the fellow eye is known as the sympathetic eye
Give an example of type I hypersensitivity affecting the eye
Allergic conjunctivitis
Give an example of type II hypersensitivity affecting the eye
Ocular cicatricial pemphigoid
Give an example of type III hypersensitivity affecting the eye
Corneal melt
Give an example of type IV hypersensitivity affecting the eye
Corneal graft rejection
