Impaired/Defective Production Anemia

Question 1

Impaired/ defective production anemia

Answer 1

Iron deficiency anemia
Anemia of chronic disease
Sideroblastic anemia
Thalassemia
Lead poisoning
Porphyrias
Megaloblastic Anemia
Aplastic anemia
Myelophthistic anemia (BM Replacement)

Question 2

Most common form of anemia

Answer 2

IDA

Question 3

Low serum iron, ferritin, hgb/hct, RBC indices, retics count

Answer 3

IDA

Question 4

IDA increase in

Answer 4

RDW and TIBC

Question 5

Inability to use available normal RBC

Answer 5

ACD

Question 6

ACD is a impaired release of storage iron associated with increased __________ level

Answer 6

Hepcidin

Question 7

Associated with persistent infection, chronic inflammatory disorder

Answer 7

ACD

Question 8

ACD increased in

Answer 8

ESR, ferritin

Question 9

ACD decrease in

Answer 9

Serum iron and TICB

Question 10

Caused by blocks on the protoporphyrin pathway resulting in defective hemoglobin synthesis and iron overload

Answer 10

Sideroblastic anemia

Question 11

Seen in sideroblastic anemia

Answer 11

2 rbc population (Dimorphic)

Question 12

Increased ferritin and serum iron

Answer 12

Sideroblastic anemia

Question 13

Excess iron accumulates in _____________ in immature erythrocytes (ringed sideroblast)

Answer 13

Mitochondrial region

Question 14

Decreased TIBC

Answer 14

sideroblastic anemia

Question 15

Increase in TIBC

Answer 15

iron deficiency anemia

Question 16

Normal to decrease in TICB

Answer 16

Thalassemia

Question 17

Inherited blood disorder that causes body to less hemoglobin than normal

Answer 17

Thalassemia

Question 18

Multiple block of protoporphyrin pathway

Answer 18

Lead poisoning

Question 19

Normocytic Normochromic anemia with BASOPHILIC STIPPLING

Answer 19

Lead poisoning

Question 20

Group of inherited disorder by a block in the protoporphyrin pathway

Answer 20

Porphyrias

Question 21

Hematologic findings are insignificant

Answer 21

Porphyrias

Question 22

Defective DNA synthesis causes abnormal nuclear maturation

Answer 22

Megaloblastic anemia

Question 23

RNA is Normal, so Cytoplasm is _______

Answer 23

Not affected

Question 24

Nucleus matures slower than cytoplasm (asynchronism)

Answer 24

Megaloblastic anemia

Question 25

Bone marrow failure

Answer 25

Aplastic anemia

Question 26

Aplastic anemia decrease in

Answer 26

Hgb/hct
Retics

Question 27

Hypoproliferative Anemia caused by replacement of bone marrow by malignant cell fibrotic tissue

Answer 27

Myelophthistic anemia