Infectious Diseases

Question 1

Antibodies directed against proteinase-3 detected as diffuse granular cytoplasmic staining pattern in neutrophils

Answer 1

cANCA (cytoplasmic anti-neutrophil cytoplasmic antibodies)

Question 2

Antibodies directed against myeloperoxidase with perinuclear or nuclear staining in neutrophils

Answer 2

pANCA (perinuclear antineutrophil cytoplasmic antibodies)

Question 3

First step in the workup of a patient with suspected vasculitis

Answer 3

Exclude other diseases

Question 4

Symptoms suggestive of vasculitis

Answer 4

Palpable purpura, pulmonary infiltrates, microscopic hematuria, chronic inflammatory sinusitis, mononeuritis multiplex, unexplained ischemic events and glomerulonephritis

Question 5

Granulomatous necrotizing vasculitis of the triad of upper and

Answer 5

Wegener’s granulomatosis

Question 6

Non-granulomatous inflammation of small arteries and veins including venules, glomerulonephritis, usually with no upper airway involvementand no pulmonarynodules, (+) pANCA

Answer 6

Microscopic polyangitis

Question 7

Asthma, peripheral and tissue eosinophila, extravascular

Answer 7

Churg-Strauss

Question 8

Necrotizing vasculitis, renal and visceral artery involvement with aneurysmal dilatations, no pulmonary artery involvement, associated with Hepatitis B

Answer 8

polyarteritis nodosa

Question 9

Elderly , presenting with fever, anemia, headaches, temporal

Answer 9

Giant cell/temporal arteritis

Question 10

Syndrome characterized by stiffness aching and pain in the muscles of the neck, shoulders, lower back, hips and thighs associated with giant cell arteritis

Answer 10

Ischemic optic neuropathy

Question 11

Y= young female, systemic symptoms, arm claudication,

Answer 11

Takayasu’s arteritis (also known as Aortic Arch Syndrome or

Question 12

Child with glomerulonephritis, palpable purpura over the buttocks and lower extremities, gastrointestinal symptoms, arthralgias, and history of recent respiratory infection

Answer 12

Henoch Schonlein Purpura (HSP)

Question 13

Most commonly encountered vasculitis in clinical practice

Answer 13

Cutaneous vasculitis

Question 14

So far the most effective therapy for the systemic vasculitides

Answer 14

Cyclophosphamide

Question 15

Cutaneous vasculitis, arthriti, peripheral neuropathy,membranoproliferative glomerulonephritis, Hepatitis C, cold-, precipitated agglutinins or immunoglobulins

Answer 15

Cryglobulinemic vasculitis

Question 16

Drugs implicated in vasculitis syndromes

Answer 16

Allopurinol, Thiazides, Gold, Sulfonamides, Phenytoin

Question 17

Malar rash, Goltron’s papules, erythematous periorbital rash (heliotrope rash), shawl and face rash, mechanic’s hands, high creatinine kinase, (+) ANA, (+) anti-Jo-1, anti-SRP and anti-Mi-2

Answer 17

Dermatomyositis

Question 18

Calcinosis, Raynaud’s phenomenom, Esophageal dysmotility, Sclerodactyly, Telangiectasia

Answer 18

CREST Syndrome (Limited Scleroderma)