inflammation

Question 1

macrophages have ____ and make ___

Answer 1

cyclo oxygenase and make PGE, PGF (prostaglandins) during first 24-72 hours

Question 2

Platelets

Answer 2

have cyclo oxygenase and make Thromaxane A2 TXA2

Question 3

Epithelial cells

Answer 3

cycoloxygenase to make PGI2

Question 4

Neutrophils

Answer 4

use lipoxygenase to make leukotriene B4 (LTB4)–chemotaxic, recruits more neutrophils

Question 5

Mast cells have

Answer 5

lipooxygenase and make LTC,D,E

Slow mediators of anaphylaxis

Question 6

NSAIDS

Answer 6

inhibit cyclooxygenases

Question 7

Leukotriene inhibtion

Answer 7

lipoxygenase inhibitors, LTE receptor blocker

treat asthma, may cause infection because of less neutrophils migration

Question 8

Inflammatory cytokines causing fever

Answer 8

IL-1, IL-6, TNF alpha

Question 9

Il-8

Answer 9

CXCL8, endothelila cell migration, angiogenesis

Question 10

MCP1

Answer 10

macrophages make it, monocyte chemotaxis

histamine release from mast cells= inflammatory chemokine

Question 11

RANTES, MIP1

Answer 11

eosinophil chemotaxis, released by macrphages and mast cells==inflammatory chemokine

Question 12

TLR4 and its co-receptor?

Answer 12

on macrophages. works with CD14 to bind LPS on G- bacteria
= fever and inflammation
endothelial cell activation= increased permeability, increased adhesion molecule expression, inhibition of anticoagulation factors, switch to pro-coagulation.

Question 13

TNF beta compared to TNF alph?

Answer 13

doesnt induce shock

Question 14

Granuloma formation dependent on?

Answer 14

IFN gamma and TNF from CD4 cells

Question 15

Cytokine cells make ____ to enhance ____

Answer 15

IL8, MCP1, RANTES, MIP-1; enhance chemotaxis

Question 16

IL-1 vs TNF alpha

Answer 16

Both cause fever, activate endothelium, release ACP.

TNF alpha ALSO induces MHC I expression, tumor necrosis, and stimulates angiogensis

Question 17

IL-15=

Answer 17

made by macrophages to enhance immune response.