Inflammatory mediators Flashcards
What does IL-1 do?
Causes fever and acute inflammation. Activates endothelium to express adhesion molecules. Induces chemokine secretion to recruit WBCs.
What does IL-2 do?
Stimulates growth of helper, cytotoxic and regulatory T cells, as well as NK cells.
What does IL-3 do?
Supports growth and differentiation of bone marrow stem cells. Functions like GM-CSF.
What does IL-4 do?
Induces differentiation of T cells into Th2 cells. Promotes growth of B cells. Enhances class switching to IgE and IgG.
What does IL-5 do?
Promotes growth and differentiation of B cells. Enhances class switching to IgA. Stimulates growth and differentiation of eosinophils.
What does IL-6 do?
Causes fever and stimulates to production of acute phase reactants.
What does IL-8 do?
Major chemotactic factor for neutrophils.
What does IL-10 do?
Attenuates the inflammatory response. Decreases MHC class II and Th1 cytokines. Inhibits activated macrophages and dendritic cells.
What does IL-12 do?
Induces differentiation of T cells into Th1 cells. Activates NK cells.
What does TNF-a do?
Activates endothelium. Causes WBC recruitment and vascular leak.
Per UWorld it also induces and maintains granuloma formation.
What does INF-gamma do?
Stimulates macrophages to kill phagocytosed pathogens. Inhibits differentiation of Th2 cells.
Which cytokines are secreted by macrophages?
IL-1, IL-6, IL-8, IL-12, TNF-alpha
Which cytokines are secreted by all T cells?
IL-2, IL-3
Which cytokines are secreted by Th2 cells?
IL-4, IL-5, IL-10
What secretes INF-gamma? In response to what?
Secreted by NK and Th1 cells in response to antigen or IL-12 from macrophages.
