Insulins

Question 1

Ultra Rapid Onset Insulin(s)

Answer 1

Lispro (Humalog)
Aspart (Novolog)
Glulisine (Aprida)

Question 2

Mechanism of action of Insulin Lispro (Humalog)

Answer 2

P28 and K29 switch locations preventing dimerization

Decreases glucose production and increases glucose utilization

Question 3

Mechanism of action of Insulin Aspart (Novolog)

Answer 3

P28 is changes to D28, prevents dimerization

Decreases glucose production and increases glucose utilization

Question 4

Mechanism of action of Insulin Glulisine (Aprida)

Answer 4

Change of N3 to K3 and L29 to E29, prevents dimerization

Decreases glucose production and increases glucose utilization

Question 5

When is the time of onset in ultra rapid insulins?

Answer 5

15-30min

Question 6

What is the duration of action of ultra rapid insulins?

Answer 6

3-5 hours

Question 7

When is the peak action of ultra rapid insulins reached?

Answer 7

1-2 hours

Question 8

Dosage forms of Insulin Lispro (Humalog)

Answer 8

Pen, vial, cartridge

Question 9

Dosage forms of insulin Glulisine (Aprida)

Answer 9

Cartridge and pen system

Question 10

Dosage forms of insulin Aspart (Novolog)

Answer 10

Pen, vial, cartridge

Question 11

Short Acting Insulin(s)

Answer 11

Regular Insulin (Humulin R)

Question 12

Dosage forms of Regular Insulin (Humulin R)

Answer 12

Pen, vial, cartridge

Question 13

When is the onset of Insulin Regular (Humulin R)?

Answer 13

30-60 min

Question 14

What is the duration of action of insulin Regular (Humulin R) ?

Answer 14

4-6hrs

Question 15

When is the peak concentration of insulin Regular (Humulin R) reached?

Answer 15

2-3 hrs

Question 16

What other insulin(s) is Insulin Regular (Humulin R) compatible with?

Answer 16

NPH

Question 17

What other insulin(s) is Insulin Glulisine (Aprida) compatible with?

Answer 17

NPH

Question 18

What other insulin(s) is Insulin Lispro (Humolog) compatible with?

Answer 18

NPH

Question 19

What other insulin(s) is Insulin Aspart (Novolog) compatible with?

Answer 19

NPH

Question 20

Intermediate acting insulin(s)

Answer 20

NPH

Question 21

Doage forms of NPH

Answer 21

Pen, vial

Question 22

When is the peak concentration of NPH reached?

Answer 22

4-8hrs

Question 23

When is the onset of NPH?

Answer 23

2-4hrs

Question 24

What is the duration of action of NPH?

Answer 24

8-12 hrs

Question 25

What other insulin(s) is NPH compatible with?

Answer 25

Regular Lispro Aspart Glulisine

Question 26

Long acting insulin(s)

Answer 26

Glargine (Lantus) | Detemir (Levemir)

Question 27

Dosage forms of Insulin Glargine

Answer 27

Pen, vial, cartridge

Question 28

Doage forms of insulin Detemir (Levemir)

Answer 28

Pen, vial, cartridge

Question 29

When is the onset of insulin Glargine (Lantus)?

Answer 29

4-5 hrs

Question 30

When is the onset of insulin Detemir (Levemir)?

Answer 30

2 hrs

Question 31

When is the peak concentration of insulin Glargine (Lantus) reached?

Answer 31

N/A

Question 32

When is the peak concentration of insulin Detemir (Levemir) reached?

Answer 32

N/A

Question 33

What is the duration of action of insulin Glargine (Lantus)?

Answer 33

22-24 hrs

Question 34

What is the duration of action of insulin Detemir (Levemir)?

Answer 34

14-24hrs | some pts are dosed BID due to the large range of DOA

Question 35

What other insulin(s) is insulin Detemir (Levemir) compatible with?

Answer 35

None

Question 36

What other insulin(s) is insulin Glargine (Lantus) compatible with?

Answer 36

None

Question 37

Ultra long acting insulin(s)

Answer 37

Degludec (Tresiba)

Question 38

Dosage forms for Degludec (Tresiba)

Answer 38

Pen

Question 39

When is the onset of insulin Degludec (Tresiba)?

Answer 39

1-2hrs

Question 40

When is the peak concentration of Degludec (Tresiba)?

Answer 40

N/A

Question 41

What is the duration of action for Degludec (Tresiba)?

Answer 41

Over 24hrs (~40hrs)

Question 42

What other insulin(s) is insulin Degludec (Tresiba) compatible with?

Answer 42

None

Question 43

Name the concentrated insulins (5)

Answer 43

Humulin-R U500 Degludec U200 (Tresiba) Glargine U300 (Toujeo) Glargine U 300 (Toujeo Max) Lispro U200 (Humalog Kwikpen)

Question 44

What is the maximum single dose delivery of Humulin R U500?

Answer 44

300units

Question 45

What is the maximum single dose delivery of Degludec U200?

Answer 45

160units

Question 46

What is the maximum single dose delivery of Toujeo (Glargine U300)

Answer 46

80units

Question 47

What is the maximum single dose delivery of Toujeo Max (Glargine U300)

Answer 47

160units

Question 48

What is the maximum single dose delivery of Humalog Kwikpen (Lispro U200)

Answer 48

60units

Question 49

What is the duration of action of Humulin R U500?

Answer 49

6-10hrs

Question 50

What is the duration of action of Degludec U200 (Tresiba)?

Answer 50

42hrs

Question 51

What is the duration of action of Glargine U300 (Toujeo and Toujeo Max)?

Answer 51

>30hrs

Question 52

What is the duration of action of Lispro U200 (Humalog Kwikpen)?

Answer 52

3-4hrs

Question 53

How many units are in the Humulin R U500 pen?

Answer 53

1500units/3mL pen

Question 54

How many units are in th Degludec U200 (Tresiba) pen?

Answer 54

600units/3mL pen

Question 55

How many units are in the Glargine U300 (Toujeo) pen?

Answer 55

450units/1.5mL pen

Question 56

How many units are in the Glargine U300 (Toujeo Max) pen?

Answer 56

900units/3mL pen

Question 57

How many units are in the Lispro U200 Humalog Kwikpen?

Answer 57

600units/3mL pen