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3211 pharma > Ion channel + Vasoactive Peptide > Flashcards

Ion channel + Vasoactive Peptide Flashcards

1
Q

what are ion channels

A

integral membrane proteins that allow ions to flow from different compartments

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2
Q

what is the function of ion channels

A
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3
Q

How is voltage-gated channel controlled and example of voltage-gated channel

A
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4
Q

Name 2 drugs that act on voltage-gated channel

A

cocaine
lidocaine

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5
Q

what channel is the Gaba receptor
and how is it controlled

A
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6
Q

Name 2 drugs that act on Gaba receptor

A
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7
Q

Nicotinic Acetylcholine receptor is what type of gated channel
how is it controlled

A
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8
Q

Name the antagonist and agonist of nicotinic acetylcholine receptor

A
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9
Q

Explain ion channel mechanism of action potential

A
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10
Q

Name a disease that is associated with ion channel function I

A

cystic fibrosis (deletion of phenylalanine at position 508)

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11
Q

Name a disease that is associated with ion channel function II

A

Long QT syndrome (mutation in cardiac potassium channel, loss in function)

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12
Q

What is the MOA of angiotensins

A
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13
Q

what is the renin -angiotensin system

A
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14
Q

what is the effect of angiotensin on cardiovascular system

A

increase blood pressure

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15
Q

what is the effect of angiotensin on adrenal gland

A
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16
Q

what is the effect of angiotensin on kidney

A

increase sodium and water reabsorption

17
Q

what is the effect of angiotensin on CNS

A
18
Q

what are the clinical use of angiotensins

A
19
Q

Name 3 types of ATII antagonist
-name the drugs under each type

A
20
Q

what is ACE inhibitor
name 2 example of ACE inhibitor

A

-prils
enalapril
captopril

21
Q

what is the therapeutic use of ACE inhibitor

A
22
Q

What is sartans, e.g losartan,valsartan

A

AT1 antagonist

23
Q

when do you use sartans

A
24
Q

what is renin inhibitor

A

aliskiren

25
Q

what is a vasopressin

A
26
Q

what is the MOA of vasopressin

A
27
Q

name 3 examples of vasopressin receptor agonist

A

vasopressin
selepressin
desmopressin

28
Q

what is the clinical use of desmopressin

A

ADH sensitive diabetes insipidus,

29
Q

what is conivaptan

A

vasopressin antagonist, non selective

30
Q

when do you use conivaptan

A

SIADH

31
Q

what is tolvaptan

A

vasopressin antagonist, 30 fold

32
Q

tolvaptan has more affinity to which receptor?

A

30 fold V2 > V1

3211 pharma (6 decks)

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