Kartagener's syndrome

Question 1

Pathology?

Answer 1

Dynein arm defect results in immotile cilia

Question 2

Features?

Answer 2

• dextrocardia or complete situs inversus
• bronchiectasis
• recurrent sinusitis
• subfertility (secondary to diminished sperm motility and defective ciliary action in the fallopian tubes)

Question 3

What may be seen with dextrocardia?

Answer 3

• quiet heart sounds

- small volume complexes in lateral leads