Kinases And zymogens Flashcards
What can kinases do
Change the activity of other proteins
What change when a conformational change occurs in a protein
Torsion angle changes
In a kinase, what is phosphorylated to activate it
The threonine residue or serine residue is phosphorylated
What enzyme activated an inactive CDK in a Cyclin/CDK complex
CDK-activating kinase- it phosphorylates the CDK
What are the two sites on a kinase
Active site- where the substrate binds
Regulatory site- where phosphorylation occurs
The regulatory site isn’t in the active site
Where does the CDK bind on this protein. Also label the active site, atp and the regulatory site
How does the active site of cyclin open and close
The third phosphate on ATP (the gamma phosphate) will be transferred to the threonine residue of CDK - this open
