L6 - Obesity

Question 1

Short term regulation of appetite via

Answer 1

1. Appetite signals
2. Fullness
3. Hunger

Question 2

Appetite signals

Answer 2

• falling glucose
• falling other nutrients, amino acids?
• Ghrelin

Question 3

Fullness detected by

Answer 3

• stretch
• nutrient chemoreceptors
• gut hormones

Question 4

Hunger

Answer 4

• homeostatic pathways e.g. leptin

- low leptin after 48 hrs

Question 5

Describe long term regulation of appetite?

Answer 5

• fat stores
• leptin made in adipose tissue
• high [leptin] post threshold don’t provide additional suppression

Question 6

what receptors in the paraventricular nuclei increase food intake?

Answer 6

NPY Y5 receptors.

NPY stimulates appetitie.

Question 7

where does alpha MSH come from and what does it do?

Answer 7

• comes from POMC
• inhibits appetite
• Proopiomelanocortin (POMC) is the pituitary precursor of circulating melanocyte stimulating hormone (α-MSH), adrenocorticotropin hormone (ACTH)

Question 8

What causes prader-willi syndrome?

Answer 8

• imprinting defect on chromosome 15

Question 9

Some signs of Prader-Willi syndrome?

Answer 9

• small hands and feet
• almond shaped eyes
• learning difficulties
• hypotonic infants
• ravenous appetitie

Question 10

Potential anti-obesity drugs

Answer 10

1. Leptin: if you’re leptin deficient
2. Orlistat: blocks fat absorption
3. GLP-1 agonist