Lect 1 Flashcards

1
Q

CNS

A

Brain and spinal cord

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2
Q

PNS

A

Autonomic and somatic

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3
Q

Sympathetic pregang

A

Preganglinic short/ACh

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4
Q

Symp preganglionic exit

A

T1-L2 Symp chain synapse in ganglia or exit as sympathies nerve to synapse in peripheral ganglia

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5
Q

Sympathetic postganglionic

A

Long NE (except sweat gland which is ACh)

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6
Q

Parasympathetic pregang

A

Long ACh

CN III VII IX X and sacrum

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7
Q

Parasympathetic postganglionic

A

Very short

ACh

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8
Q

Adrenergic receptors respond to

A

NE

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9
Q

Alpha 1 adrenergic receptor

A

Vasoconstriction

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10
Q

Alpha 2

A

Presnaptic FB inhibition

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11
Q

Beta 1

A

Increase heart rate

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12
Q

Beta 2

A

Bronchodilation

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13
Q

Cholinergic receptors respond to

A

ACh

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14
Q

Nicotinic 1

A

Skeletal muscle

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15
Q

Nicotinic 2

A

Post synaptic cholinergic and adrenergic nerves

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16
Q

Muscarinic

A

Heart and lungs slow/contract (conserve energy) salivary gland salivate
Eye constriction

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17
Q

Direct acting cholinomimetic drugs act

A

Like ACh on cholinergic receptros

18
Q

Cholinergic esters

A

ACh in vivo

Methacholine
Carbachol
Bethanechol

19
Q

Methacholine

A

Bronchial challenge test

20
Q

Carbachol

A

Eye surgery

21
Q

Bethanechol

A

Dry mouth

22
Q

Cholinergic alkaloids

A

Muscarine-poisonous mushrooms
Pilocarpine
Nicotine
Lobeline

23
Q

Pilocarpine

A

Saliva production

24
Q

Nicotine

A

Stimulate from nightshade

25
Q

Indirect acting cholinomimetic drugs

A

Inhibit AChE

26
Q

Quaternary amides +

A

All treat myasthenia gravis

Neostigmine
Edrophonium
Pyridogimine

27
Q

Tertiary amides

A

Phsyostigmine-anticholinergics syndrome

28
Q

Tertiary amides can

A

Pass BBB because neutral

29
Q

Organophosphate

A

Echothiphate
Malathion
Parathion
Sarin

30
Q

Echothiphate

A

Glaucoma

31
Q

Malathion

A

Anti parasite

32
Q

Parathion

A

Inspected ice

33
Q

Sarin

A

Deadly nerve gases

34
Q

Muscarinic R blockers (anticholinergics)

A

Quaternary amides and tertiary amide

35
Q

Muscarinic R blockers (anticholinergics) quaternary

A

Glycopyrolate
Propantheline
Ipratoproum

36
Q

Glycopyrrolate

A

Bradycardia

37
Q

Propantheline

A

Excessive sweating

38
Q

Ipratopium

A

Asthma

39
Q

Muscarinic R blockers (anticholinergics) tertiary amides

A

Atropine
Scopolamine
Benztropine

40
Q

Atropine

A

Bradycardia

41
Q

Scopolamine

A

PONV

42
Q

Benztropine

A

Parkinson’s disease