Lecture 12

Question 1

Define absorption

Answer 1

Drug transfer from its site of administration to the systemic circulation (blood).

Question 2

What are the routes of drug administration

Answer 2

Enteral
Oral
Rectal

Parenteral

Question 3

What are the factors that influence enteral absorption

Answer 3

Gastrointestinal (GI) motility

GI blood flow

Drug particle size and formulation

Drug physicochemical properties

Question 4

What is the equation for bioavailability

Answer 4

Bioavailability=Oral AUC/IV AUC

Question 5

Describe the first pass (pre-systemic) metabolism

Answer 5

This refers to metabolism of the drug prior to reaching systemic circulation.

First pass effect →Bioavailability