lecture 16 Flashcards
Meiosis has two consecutive nuclear divisions, resulting in daughter cells with half the number of chromosomes as the parent cell
true dat
The eukaryotic cell cycle consists of several phases and is regulated by a molecular control system
true dat
The eukaryotic cell cycle is controlled by specific molecular signals that trigger the transition from one phase to another
true dat
Most _____ cells of a multicellular eukaryote are arrested in G1 phase
somatic
During development, growth, repair, or normal cell replacement cells progress through the cell cycle
yepp
Cyclins are synthesized during __
G1
CDK activation occurs in the presence of ____
cyclin
Cyclins are _____ and ______
transient
unstable
Progression from G1 to S requires active _____
CDK
g1-s CDK _______ Retinoblastoma (RB) proteins
phosphorylates
Unphsphorylated RB ____ the cell cycle at restriction point; cell does not enter S phase
inhibits
G1S CDK essentially disables RB so RB doesn’t inhibit the cell cycle
true dat
When RB is phosphorylated by G1-s cyclin-CDK, cell becomes committed to ______ DNA
replicating
IF there is DNA damage in G1, p21 protein _____ activation of G1-S CDK
prevents