Lecture 3: Chemistry & Targets Flashcards
1
Q
Why is omeprazole formulated in hard gelatine capsules?
A
To prevent conversion to the sulphenamide whilst in the stomach
2
Q
What is the dose for omeprazole for duodenal ulcers?
A
20mg dose daily for 2-4 weeks
3
Q
What is the dose for omeprazole for gastric ulcers?
A
20mg dose dialy for up to 8 weeks
4
Q
Compare the enantiomers of omeprazole
A
R-enantiomer produced 15% gastric acid inhibition where as the S-enantiomer gave 90% inhibition, S enantiomer was prepared as esomeprazole. S more potent
