LESSON 4 Flashcards
is a protective universal
response to tissue damage (mechanical trauma,
tissue necrosis, infection)
INFLAMMATION
Body’s response to infection
◆ There is an increase in temperature to kill
microorganism
◆ A response that induces inflammation
◆ Sometimes, there is no swelling but there is
an increase in temperature to indicate that it
will further lead to inflammation.
INFLAMMATION
It is described by Celsius.
refers to the first or major symptoms of
a disease.
CARDINAL SIGNS OF INFLAMMATION
it is only apparent to the
patient.
Symptoms
Cardinal Signs: (Latin words)
1. _______ – Redness
2. ______ – Heat
3. _______-– Swelling
4. _______– Pain
5. _________ – Loss of Function
Cardinal Signs: (Latin words)
1. Rubor – Redness
2. Calor – Heat
3. Tumor – Swelling
4. Dolor – Pain
5. Functio laesa – Loss of Function
Redness → heat → swelling → pain →
loss of function
Why is there heat (calor)?
Because there is capillary
widening or vasodilation, where the capillary is
expanding and will result in an increase in blood flow,
which is why heat occurs. (kaya mainit)
______________ means that water can enter and
escape quickly (ease of passage), and its
effect is where fluid is released into the
tissues.
Permeability
Increased diameter of blood
vessels → Increased blood flow
to the area → Erythema (heat
and redness on site of infection)
Vasodilation
Lack of blood
flow in the certain area
Ischemia
Increased vascular permeability
→ Edema (extravasion of liquid
portion of blood)
III. Endothelial
Activation
WBC enters site of injury
Neutrophil
Activation
SEQUENTIAL STEPS OF A TYPICAL
INFLAMMATORY REACTION
- Recognition of stimulus
- Recruitment of WBCs and proteins to site
- Removal of stimulus
- Regulation of response
- Repair
Recognition → recruitment → removal →
regulation → repair.
understand what the situation
is and what are needed
Recognition
recruit cells that are needed
Recruitment
(removal of stimulus)
– monocyte and/or granulocytes kills the
microbes. They kill the organism and also
mount the degrees
➔ After the WBCs are called, removal
of stimulus will happen.
Elimination of microbes