Lipids Flashcards

1
Q

what is lipogenesis

A

storing FA as triglycerides in liver and adipose tissue

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2
Q

What role do triglycerides do in the liver

A

make lipoproteins

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3
Q

what are lipoproteins

A

cholesterol
phospholipids
proteins
triglycerides

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4
Q

what is lipolysis + rxn that does it

A

breakdown of stored triglycerides to release free FA and glycerol vis hydrolysis

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5
Q

what are dietary fats

A

FA packaged into chylomirons for transport to tissues

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6
Q

what are the 3 steps of lipolysis

A
  1. TAG –> DAG + ffa
  2. DAG –> MAG + ffa
  3. MAG –> glycerol + ffa
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7
Q

what enzyme turns TAG –> DAG

A

adipose triglyceride lipase

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8
Q

what enzyme turns DAG –> MAG

A

hormone sensitive lipase (HSL)

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9
Q

what enzyme turns MAG –> glycerol + ffa

A

monoglyceride lipase

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10
Q

what hormones regulate HSL

A

glucagon
insulin
epinephrine

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11
Q

what activates HSL

A

glucagon and epinephrine

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12
Q

what inactivates HSL

A

insulin

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13
Q

what is beta oxidation

A

process of breaking down ffa into energy

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14
Q

step 1 of beta oxidation

A

FA activation = 2 ATP worth of energy
requires 2 hydrolysis rxns
ATP–> AMP + PPi
PPi –> Pi + Pi

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15
Q

where does step 1 of beta oxidation occur

A

cytosol

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16
Q

how do fatty acyl CoA get into the mitochondria

A

carnitine transport system

17
Q

How to you find the number of acetyl CoA’s

A

divide # of Carbons by 2

18
Q

how do you determine the number of cycles of beta oxidation

A

acetyl CoA # - 1 = # of cycles

19
Q

what does # of cycles also show

A

of NADH and FADH2

20
Q

each acetyl CoA through CAC makes how much ATP (inld net)

A

12 ATP
(10 ATP net as 2 for FA activation)

21
Q

What is the cause of MCAD deficiency

A

low oxaloacetate so less GNG = low acetyl CoA levels